赤子爱胜蚓纤溶酶对大鼠血小板聚集性的药理作用观察

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (4): 291-294.

赤子爱胜蚓纤溶酶对大鼠血小板聚集性的药理作用观察

姜东胜¹, 刘复强¹, 赵相印¹, 孔维红², 王珏英³, 陈滨凌³, 卢静³

1. 首都医学院附属北京同仁医院中心实验室;2. 中国医学科学院肿瘤医院内科;3. 上海医科大学药学院药理学教研室

收稿日期:1993-10-18 修回日期:1900-01-01 出版日期:1994-10-15 发布日期:1994-10-15

The Study on Pharmacological Effect of Fibrinolytic Components of Earthworm on Platelet Aggregation in Rats

Jiang Dongsheng¹, Lu Fuqiang¹, Zhao Xiangyin¹, Kong Weihong Wang Jueying², Chen Binling³, Lu Jing³

1. Central Laboratory, Tongren Hospital, Capital institute of Medicine;2. Cancer Hospital, CAMS and PUMC;3. Department of Pharmocology, Shanghai Medical University

Received:1993-10-18 Revised:1900-01-01 Online:1994-10-15 Published:1994-10-15

摘要/Abstract

摘要： 利用动物体内和体外不同的实验模型研究发现用赤子爱胜蚓纤溶酶给动物灌胃或静脉注射,均表现出显着的抗血小板聚集效应,表明本提取物在一定程度上具有抗凝血作用.另外,我们利用体外模拟血栓形成条件实验模型方法观察发现,蚯蚓纤溶活性成分尚有明显的抗血栓形成药理作用,对蚯蚓纤溶活性成分进一步研究和开发有可能为血栓性疾病的预防和治疗提供一种新型药物.

关键词: 蚯蚓, 血小板聚集, 实验性血栓

Abstract: It was reported that there were rich fibrinolytic substances in the tissue of earthworm Eisenia foelide and this was also verified in our previous work after its purification and in vitro study of its fibrinolytic activities by various methods. So far,we have studied the fibrinolytic extracts of earthworm for several years,and we have established certain procedures of purification. In this article,we studied the pharmacological effects of this extract on the aggregation of platelets of animals. The extract showed prominent anti-platelet aggregation effect after its oral administration in vitro and in vivo. The results showed that this fibrinolytic extract has anti-coagulation effect. And it is potential to be studied further,and perhaps, it may be developed into a new kind of drug to treat and to prevent the thrombotic diseases.

Key words: earthworm, platelet aggregation, experimental thrombosis

中图分类号:

R973.2

姜东胜;刘复强;赵相印;孔维红;王珏英;陈滨凌;卢静. 赤子爱胜蚓纤溶酶对大鼠血小板聚集性的药理作用观察[J]. 首都医科大学学报, 1994, 15(4): 291-294.

Jiang Dongsheng;Lu Fuqiang;Zhao Xiangyin;Kong Weihong Wang Jueying;Chen Binling;Lu Jing. The Study on Pharmacological Effect of Fibrinolytic Components of Earthworm on Platelet Aggregation in Rats[J]. Journal of Capital Medical University, 1994, 15(4): 291-294.

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