分枝杆菌多糖治疗类风湿关节炎的临床观察

首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (1): 33-36.

分枝杆菌多糖治疗类风湿关节炎的临床观察

左大鹏¹, 王秋萍¹, 张京秀¹, 陈仁², 张则正³

1. 首都医科大学附属北京同仁医院检验科;2. 首都医科大学应用免疫学教研室;3. 首都医科大学附属北京天坛医院骨科

收稿日期:1996-03-23 修回日期:1900-01-01 出版日期:1997-01-15 发布日期:1997-01-15

A Preliminary Clinical Trial on Mycobacterial Polysaccharides in Treatment of Rheumatoid Arthritis

Zuo Dapeng¹, Wang Qiuping¹, Zhang Jingxiu¹, Chen Ren², Zhang Zezheng³

1. Tongren Hospital, Affiliate of Capital University of Medical Sciences;2. Department Applied Immunology, Capital University of Medical Sciences;3. Tiatan Hospital, Affiliate of Capita

Received:1996-03-23 Revised:1900-01-01 Online:1997-01-15 Published:1997-01-15

摘要/Abstract

摘要： 按照随机配对和交叉试验的原则,对50例活动期类风湿关节炎患者实施分枝杆菌多糖+非甾体抗炎药和甲氨喋呤+非甾体抗炎药分组治疗。结果:2组临床疗效无明显差异,但分枝杆菌多糖组治疗中副作用发生率仅为3.8%,而甲氨喋呤组却高达32%.分枝杆菌多糖可双向调节T辅助细胞和T抑制细胞的数量,而甲氨喋呤使两者均减少。研究结果提示分枝杆菌多糖可以用于类风湿关节炎的治疗。

关键词: 分枝杆菌多糖, 类风湿关节炎, 甲氨喋呤

Abstract: 50 patients with active rheumatoid arthritis who have no improvement after twomonths' treatment with NSAIDs were divided into two groups randomly. One group accepted the treatment of MPS plus NSAID.While another group accepted the treatment of MTX plus NSAID. The clinical result and the effect on patient's immune fuction had been evaluated after six months' treatment.Then the treating programs in the two groups were exachanged and continued for another six months. Once again the result and the effect were appraised . At the same time, the adverse reactions of MPS and MTX were observed. The results of the oneyear's study showed that the total effective rate was 48% in the group of MPS plus NSAID, but 60% in the group of MTX plus NSAID. Howere there was no statistical significant difference between the two groups. The observation of the side effects showed that it was 3.8% in the MPS group,but 32% in the other.The patients' CD₃ and CD₄ Tlymphocytes in peripheral blood decreased after the use of MTX, denoting that the immune function was suppressed. But by using MPS, both CD₃ and CD₄ can be regulated in two ways.This study shows that MPS can be used in the treatment of rheumatoid arthritis.

Key words: Mycobacterial polysaccharides(MPS), rheumatoid arthritis, methotrexate(MTX)

中图分类号:

R593.22

左大鹏;王秋萍;张京秀;陈仁;张则正. 分枝杆菌多糖治疗类风湿关节炎的临床观察[J]. 首都医科大学学报, 1997, 18(1): 33-36.

Zuo Dapeng;Wang Qiuping;Zhang Jingxiu;Chen Ren;Zhang Zezheng. A Preliminary Clinical Trial on Mycobacterial Polysaccharides in Treatment of Rheumatoid Arthritis[J]. Journal of Capital Medical University, 1997, 18(1): 33-36.

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