谷氨酸单钠对大鼠发育和免疫功能的影响

首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (3): 218-221.

谷氨酸单钠对大鼠发育和免疫功能的影响

李玉兰¹, 李郁英¹, 安云庆¹, 杨佩荪², 刘冬梅²

1. 首都医科大学微生物免疫学教研室;2. 首都医科大学病理解剖学教研室

收稿日期:1996-12-13 修回日期:1900-01-01 出版日期:1997-07-15 发布日期:1997-07-15

The Effect of Monosodium Glutamate on the Growth and Immue Function in Rat

Li Yulan¹, Li Yuying¹, An Yunqing¹, Yan Peisun², Liu Dongmei²

1. Department of Microbiology and Immunology, Capital University of Medical Sciences;2. Department of Pathological Anatomy, Capital University of Medical Sciences

Received:1996-12-13 Revised:1900-01-01 Online:1997-07-15 Published:1997-07-15

摘要/Abstract

摘要： 给出生10d内的Wistar大鼠隔日皮下注射谷氨酸单钠(MSG)4mg/g,观察其青春期(52日龄)时体重、垂体及重要免疫器官---胸腺和脾脏重量的变化。结果：皮下注射MSG大鼠的上述各项指标均显着低于正常对照组,体液和细胞免疫功能也明显降低(P<0.01).组织切片镜下显示：MSG组大鼠下丘脑弓状核团缩小。提示：弓状核损伤导致垂体前叶生长激素细胞不能正常合成分泌生长激素是大鼠生长迟缓和重要免疫器官发育不良的主要原因；大鼠免疫功能降低可能是由于胸腺和脾脏发育不良,从而影响淋巴细胞在其内的正常分化和免疫应答的正常发挥所致。

关键词: 谷氨酸单钠, 弓状核, 免疫功能

Abstract: Wistar newborn rats were injected subcutaneously with monosodium glutamate (MSG<320 mg). On the 52 th day, the body weight, length and the weight of immune organs——thymus and spleen were reduced significantly as compared with those in the normal rats. The immune function of rats was lower than that of the normal rats ( P<001).Morphological observation showed: The nucleus arcuatus was apparently smaller and the number of neurones became obviouly less than those in the normal rats. The results of immunohistochemical tests revealed that the number of the growth hormone secreting cells in the pituitary glands of rats treated with MSGbecame smaller. We consider that :① The reason for retarded growth of pituitary glands and immune organs is the damage of nucleus arcuatus induced by MSG, thus decreasing the secretion of growth hormone releasing factor(GHRF), therefor the secretion of growth hormone in pituicyte is insufficient. ② Poor growth of the immune organs(thymus and spleen) affects the normal development and normal immune response of T,Blymphocytes in the organs. So the immune function of rats treated with MSGis reduced.

Key words: monosodium glutamate (MSG), nucleus arcuatus, immune function

中图分类号:

Q939.1

李玉兰;李郁英;安云庆;杨佩荪;刘冬梅. 谷氨酸单钠对大鼠发育和免疫功能的影响[J]. 首都医科大学学报, 1997, 18(3): 218-221.

Li Yulan;Li Yuying;An Yunqing;Yan Peisun;Liu Dongmei. The Effect of Monosodium Glutamate on the Growth and Immue Function in Rat[J]. Journal of Capital Medical University, 1997, 18(3): 218-221.

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