分枝杆菌多糖的长期毒性实验研究

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (1): 13-18.

分枝杆菌多糖的长期毒性实验研究

吴萍¹, 苏忆兰¹, 陈振良¹, 刘桢¹, 张杰¹, 李娟¹, 蒋致诚¹, 赵文明², 陈仁²

1. 首都医科大学劳动卫生教研室;2. 首都医科大学应用免疫研究室

收稿日期:1997-04-25 修回日期:1900-01-01 出版日期:1998-01-15 发布日期:1998-01-15

A Long Term Toxicity Test of Mycobacterial Polysaccharides

Wu Ping¹, Su Yilan¹, Chen Zhenliang¹, Liu Zhen¹, Zhang Jie¹, Li Juan¹, Jiang Zhicheng¹, Zhao Wenming², Chen Ren²

1. Department of Industrial Health, Capital University of Medical Scienses;2. Department of Immunology, Capital University of Medical Sciences

Received:1997-04-25 Revised:1900-01-01 Online:1998-01-15 Published:1998-01-15

摘要/Abstract

摘要： 对分枝杆菌多糖(MPS)进行了长期毒性实验.结果:MPS 1.5、7.5、15.0μg/kg体重3个剂量组与对照组大鼠在生长发育、食物利用系数、血液常规、生化指标、脏体比和脏器病理检查等方面均无统计学上的显着差异(P>0.05).表明MPS在实验剂量范围内对大鼠无不良影响,提示它在临床上长期使用是安全的.

关键词: 分枝杆菌多糖, 免疫调节剂, 长期毒性实验

Abstract: long term toxicity test of Mycobacterial polysaccharides(MPS)was carried out. Experimental groups with three different doses(1.5、7.5 and 15.0 μg/kg)of MPS were compared with the control in the parameters of growth ratio, coefficieny of food utilization, routine and specific tests of blood, OW/BW ratio and pathological examinations. Results showed no significant statistical differences between the experimental animals and controls. This study shows that MPS with such test doses has no adverse effect to the rats denoting that MPS can be used for long term treatment.

Key words: Mycobacterial polysaccharide, immunomodulator, long term toxicity test

中图分类号:

R965.3

吴萍;苏忆兰;陈振良;刘桢;张杰;李娟;蒋致诚;赵文明;陈仁. 分枝杆菌多糖的长期毒性实验研究[J]. 首都医科大学学报, 1998, 19(1): 13-18.

Wu Ping;Su Yilan;Chen Zhenliang;Liu Zhen;Zhang Jie;Li Juan;Jiang Zhicheng;Zhao Wenming;Chen Ren. A Long Term Toxicity Test of Mycobacterial Polysaccharides[J]. Journal of Capital Medical University, 1998, 19(1): 13-18.

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