急性桐油中毒大鼠实验模型的建立及其形态学改变

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (1): 5-8.

急性桐油中毒大鼠实验模型的建立及其形态学改变

王洪超¹, 陈瑞芬¹, 宋爱丽¹, 刘国贞¹, 韩囱囱², 姚雅玲²

1. 首都医科大学病理解剖学教研室;2. 西城区德外医院内科

收稿日期:1997-09-29 修回日期:1900-01-01 出版日期:1998-01-15 发布日期:1998-01-15

Morphologic Changes of Rat Model of Moentjang Tina

Wang Hongchao¹, Chen Ruifen¹, Song Aili¹, Liu Guozhen¹, Han Zhengzheng², Yao Yaling²

1. Department of Pathology, Capital University of Medical Sciences;2. Department of Internal Medicine, Dewai Hospital Xicheng District

Received:1997-09-29 Revised:1900-01-01 Online:1998-01-15 Published:1998-01-15

摘要/Abstract

摘要： 模拟人类桐油中毒的方式,以不同剂量桐油灌喂大鼠,制作大鼠急性桐油中毒的模型.发现:不同剂量的桐油可引起不同程度的肺脏、肝脏、肾脏和心脏的损伤.而且,各脏器的损伤程度随着灌喂剂量的增加而增加.结果提示急性桐油中毒可以导致全身多个器官的损伤.

关键词: 桐油中毒, 实验模型, 形态变化

Abstract: Rat model of Moentjang tina was produced by imitating Moentjang tina of human beings with different dose of Tung oil(Aleuriter fordii), which had made 55 people poisoned. The result showed that different pathological changes, such as interstitial edema of lung, hydropic degeneration of proximal tubule, fatty degeneration of hepatocyte and loose cytoplasm of myocardium, happened in groups of different dose of Tung oil, and that the severity of injury paralleled somewhat to the amount of oil used. The experiment indicates that Tung oil can cause comprehensive injuries of different organs.

Key words: Moentjang tina, rat model, morphologic changes

中图分类号:

王洪超;陈瑞芬;宋爱丽;刘国贞;韩囱囱;姚雅玲. 急性桐油中毒大鼠实验模型的建立及其形态学改变[J]. 首都医科大学学报, 1998, 19(1): 5-8.

Wang Hongchao;Chen Ruifen;Song Aili;Liu Guozhen;Han Zhengzheng;Yao Yaling. Morphologic Changes of Rat Model of Moentjang Tina[J]. Journal of Capital Medical University, 1998, 19(1): 5-8.