γ-氨基丁酸对蟾蜍离体脊神经节神经元电活动的影响

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (2): 101-104.

γ-氨基丁酸对蟾蜍离体脊神经节神经元电活动的影响

高翠英, 吕国蔚

首都医科大学神经生物学研究室

收稿日期:1997-09-10 修回日期:1900-01-01 出版日期:1998-04-15 发布日期:1998-04-15

Effects of GABA on Electrical Activity of Spinal Ganglion Neurons in Vitro in the Toad

Gao Cuiying, Lü Guowei

Department of Neurobiology, Capital University of Medical Sciences

Received:1997-09-10 Revised:1900-01-01 Online:1998-04-15 Published:1998-04-15

摘要/Abstract

摘要： 在保留坐骨神经(Sc)和背根(Dr)的蟾蜍离体脊神经节制备上进行细胞内记录,用刺激Sc和(或)Dr的方法,诱发脊神经节(DRG)神经元动作电位,观察局部γ氨基丁酸(GABA)灌注对该诱发电活动的影响.结果:GABA灌注使DRG神经元动作电位的振幅显着降低,持续期与后超极化显着增强,对刺激频率的跟随能力显着降低.结果提示:GABA可能通过DRG神经元胞体GABA受体对DRG突触传递发挥抑制作用.

关键词: 脊神经节, γ-氨基丁酸, GABA受体, 突触传递

Abstract: Intracellular recordings were made from toad dorsal root ganglion(DRG)associated with sciatic nerve(Sc)and dorsal root(Dr)in vitro. Action potentials(AP)of DRG neurons were evoked by stimulation of Sc and(or)Dr and effects of local GABA perfusion on the evoked potentials were observed. The AP′s amplitude and duration were significantly reduced and prolonged, respectively,as the DRG was perfused with GABA solution. Its after-hyperpolarization and frequency following ability were increased and decreased, respectively under the GABA perfusion. These results indicate that GABA may exert its inhibitory role in synaptic transmission in the DRG via its receptors on the cell body of DRG neurons.

Key words: spinal ganglion neurons, GABA, GABA receptors, synaptic transmission

中图分类号:

Q426

高翠英;吕国蔚. γ-氨基丁酸对蟾蜍离体脊神经节神经元电活动的影响[J]. 首都医科大学学报, 1998, 19(2): 101-104.

Gao Cuiying;Lü Guowei . Effects of GABA on Electrical Activity of Spinal Ganglion Neurons in Vitro in the Toad[J]. Journal of Capital Medical University, 1998, 19(2): 101-104.

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