糖尿病合并脑梗塞患者血浆内皮素及降钙素基因相关肽的改变及其临床意义

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (2): 127-129.

糖尿病合并脑梗塞患者血浆内皮素及降钙素基因相关肽的改变及其临床意义

鲁梅花, 邢维常, 张人玲, 张淑敏, 寿吉平, 王丽君

首都医科大学宣武医院内分泌科

收稿日期:1997-08-25 修回日期:1900-01-01 出版日期:1998-04-15 发布日期:1998-04-15

Investigation on Plasm Concentration of CGRP and ET in NIDDM Complicated with Cerebral Infarction

Lu Meihua, Xing Weichang, Zhang Renling, Zhang Shumin, Shou Jiping, Wang Lijun

Endocrine of Xuanwu Hospital, Affiliate of Capital University of Medical Sciences

Received:1997-08-25 Revised:1900-01-01 Online:1998-04-15 Published:1998-04-15

摘要/Abstract

摘要： 观测了33例非胰岛素依赖型糖尿病(NIDDM)合并脑梗塞患者血浆内皮素(ET)及降钙素基因相关肽(CGRP)的变化.发现糖尿病合并脑梗塞组72h之内血浆ET高于脑梗塞组、糖尿病组及正常对照组,血浆CGRP低于单纯脑梗塞组,但高于糖尿病组.糖尿病伴有高血压和眼底、肾脏合并症者发生脑梗塞时比无合并症者ET升高明显,CGRP相对较低.糖尿病合并脑梗塞病人在72h内,病情危重者的ET高于轻中型者,CGRP低于轻、中型者.

关键词: 非胰岛素依赖型糖尿病, 脑梗塞, 内皮素, 降钙素基因相关肽

Abstract: The plasma concentration of CGRP(calcitonin gene related peptide)and ET(endothelin)in 33 NIDDM patients complicated with cerebral infarction were investigated. Results showed that the concentration of ET within 72 h in group of NIDDM complicated with cerebral infarction was higher than those in the rest three groups, manely simple cerebral infarction, simple NIDDM and controls(P<0.01). The concentration of CGRP in group of NIDDM complicated with cerebral infarction was lower than that in simple cerebral infarction group, but was higher than that in simple NIDDM group. When NIDDM patients complicated with hypertention, retinopathy or nephrosis suffered from cerebral infarction, their concentration of ET were higher than that in NIDDM without complication, and their concentrations of CGRP were lower than that of NIDDM without complication. In NIDDM with complicated cerebral infarction, the concentrations of ET within 72 h in severe cases were higher than ,and the concentration of CGRP were lower than those in mild or moderate cases.

Key words: NIDDM, cerebral infarction, ET, CGRP

中图分类号:

鲁梅花;邢维常;张人玲;张淑敏;寿吉平;王丽君. 糖尿病合并脑梗塞患者血浆内皮素及降钙素基因相关肽的改变及其临床意义[J]. 首都医科大学学报, 1998, 19(2): 127-129.

Lu Meihua;Xing Weichang;Zhang Renling;Zhang Shumin;Shou Jiping;Wang Lijun . Investigation on Plasm Concentration of CGRP and ET in NIDDM Complicated with Cerebral Infarction[J]. Journal of Capital Medical University, 1998, 19(2): 127-129.

[1]	徐洪涛;高连如;张宁坤;朱智明;费宇行;杨晔;王兆君;刘英明;曹毅;陈宇;李贤峰. 急性心肌梗死患者骨髓单核细胞移植前后血浆尾加压素和内皮素水平的变化[J]. 首都医科大学学报, 2010, 31(1): 99-102.
[2]	唐玉平;李鹏高;邢晓然;余振球;孙丽颖;肖忠新;张淑华;吴惠慧;褚金花;李卫新;甄亚平. 膳食补充条斑紫菜对高血压患者血管内皮功能的影响[J]. 首都医科大学学报, 2008, 29(4): 475-478.
[3]	张军;张忠涛;王宇;王萍;李建设;周延忠. 内皮素-1及其受体拮抗剂对HSC-T6细胞Ⅰ型胶原mRNA表达的作用[J]. 首都医科大学学报, 2007, 28(1): 68-70.
[4]	王云帆;李海燕;刘国贞;陈瑞芬. 内皮素在急性出血坏死性胰腺炎肾损害中的作用[J]. 首都医科大学学报, 2007, 28(1): 56-60.
[5]	薛纪秀;王克杰;程维涛;刘清海;范隆. 腹膜后CO₂充气对脑血流及血管活性肽的影响[J]. 首都医科大学学报, 2006, 27(5): 594-596.
[6]	付慧芳;陈瑞;于培兰;孙林;谭延国. 高压氧对大鼠短暂脑缺血降钙素基因相关肽和β-内啡肽的影响[J]. 首都医科大学学报, 2005, 26(4): 435-437.
[7]	李梅;华琦;刘荣坤;杨铮. 高血压合并心房颤动对内皮细胞功能的影响[J]. 首都医科大学学报, 2005, 26(3): 312-315.
[8]	王力增;黄雯;姜丽萍;代浩洁;王颖. 慢性肾炎患者内皮素、降钙素基因相关肽变化的临床意义[J]. 首都医科大学学报, 2004, 25(1): 89-91.
[9]	苏红星;猪口哲夫;浜崎正雄. 豚鼠胆囊SP及CGRP免疫反应神经纤维的光镜和电镜观察[J]. 首都医科大学学报, 2002, 23(2): 110-112.
[10]	石蕾;赵轶文;张小平;单若明. 血、尿内皮素水平与肾性高血压的研究[J]. 首都医科大学学报, 2001, 22(2): 135-137.
[11]	石蕾;赵轶文;张小平;单若明. 慢性肾炎患者水钠潴留与PET相关性研究[J]. 首都医科大学学报, 2000, 21(2): 118-119.
[12]	顾海彤;谭杰;武宝玉. 84例非胰岛素依赖型糖尿病患者肺功能改变的探讨[J]. 首都医科大学学报, 1999, 20(3): 189-191.
[13]	姚晓苓;汪家瑞;孙惠玲;邢维常;苏文娟;曹心民;白丹. 心肌梗塞合并糖尿病患者血管紧张素转换酶基因多态性分析[J]. 首都医科大学学报, 1998, 19(4): 331-334.
[14]	钱玉英;陈秉良. 老年NIDDM患者微量白蛋白尿与脂质代谢的关系及临床意义[J]. 首都医科大学学报, 1998, 19(4): 352-354.
[15]	王星宇;孔锋;张丽蓉;李忠如;艾厚喜;盛树力. 突发性聋患者血浆内皮素-1和降钙素基因相关肽改变的观察[J]. 首都医科大学学报, 1998, 19(2): 168-170.