谷氨酸单钠对大鼠垂体促性腺激素细胞的影响

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (3): 213-216.

谷氨酸单钠对大鼠垂体促性腺激素细胞的影响

刘冬梅¹, 杨荪², 王蓬文², 周以健²

1. 首都医科大学附属北京天坛医院内科;2. 首都医科大学病理解剖学教研室

收稿日期:1997-10-13 修回日期:1900-01-01 出版日期:1998-07-15 发布日期:1998-07-15

Effect of Monosodium Glutamate on GTH Pituicyte in Rats

Liu Dongmei¹, Yang Peisun², Wang Pengwen², Zhou Yijian²

1. Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Pathology, Capital University of Medical Sciences

Received:1997-10-13 Revised:1900-01-01 Online:1998-07-15 Published:1998-07-15

摘要/Abstract

摘要： 给新生期大鼠皮下注射10%谷氨酸单钠(MSG),观察其青春期(52日龄)及成年期(100日龄)的垂体及黄体生成素(LH)细胞的变化。结果:青春期和成年期给药组大鼠的垂体质量分别为(3.26±0.51)mg和(5.21±0.72)mg,显着低于对照组的(8.46±0.81)mg和(12.04±1.23)mg(P<0.01);给药组的LH细胞面积(像素值)分别为998.00±161.56和1105.56±219.83,显着小于对照组的1662.30±141.46和1892.11±212.29(P<0.01).但各期给药组单个细胞内LH含量与对照组均无显着性差异(P>0.05).血清LH及卵泡刺激素(FSH)的浓度给药组各期均显着低于对照组(P<0.01).给药组弓状核神经细胞明显减少,分布稀疏。结果表明:新生期注射MSG大鼠的垂体促性腺激素(GTH)细胞的发育及功能受到抑制.

关键词: 谷氨酸单钠, 促性腺激素细胞, 黄体生成素, 卵泡刺激素

Abstract: The neonatal rats were injected subcutaneously with 10% monosodium glutamate(MSG). The development of rat pituitary gland and LH pituicyte were observed on the 52th day(puberty)and 100th day(adult). The results showed:The pituitary weights on 52th and 100th day were(3.26± 0.51)mg and(5.21±0.72)mg in MSG group respectively. They decreased significantly as compared with control group(P<0.01),(8.46±0.81)mg and(12.04±1.23)mg respectively. The mean area of LH pituicytes on 52th day and 100th day were 998.00±161.56 and 1 105.56± 219.83. They decreased remarkably as compared with control group(P<0.01), 1 662.30±141.46 and 1 892.11±212.29 respectively. However, LH content of individual LH pituicyte in MSG group had no significant differences as compared with that in control group(P>0.05). The serum concentrations of LH and FSH were significantly lower in MSG group than those of control group on both ages. A striking reduction in the number of neurons in the arcuate nucleus(ARC)were noted. Thus, MSG can depress the development and function of GTH pituicytes.

Key words: monosodium glutamate(MSG), GTH pituicyte, LH, FSH

中图分类号:

Q453

刘冬梅;杨荪;王蓬文;周以健. 谷氨酸单钠对大鼠垂体促性腺激素细胞的影响[J]. 首都医科大学学报, 1998, 19(3): 213-216.

Liu Dongmei;Yang Peisun;Wang Pengwen;Zhou Yijian. Effect of Monosodium Glutamate on GTH Pituicyte in Rats[J]. Journal of Capital Medical University, 1998, 19(3): 213-216.

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