梗阻性黄疸大鼠胃电及胃运动的实验研究

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (1): 46-48.

梗阻性黄疸大鼠胃电及胃运动的实验研究

李非¹, 孙家邦¹, 刘爽¹, 蔡伟¹, 刘素梅², 曲瑞瑶², 曾文红², 曲柏林²

1. 首都医科大学宣武医院普外科;2. 首都医科大学生理学教研室

收稿日期:1999-02-01 修回日期:1900-01-01 出版日期:2000-01-15 发布日期:2000-01-15

Gastric Electric Activity and Motility in Obstructive Jaundice Rat

Li Fei¹, Sun Jiabang¹, Liu Shuang¹, Cai Wei¹, Liu Sumei², Qu Ruiyao², Zeng Wenhong², Qu Belin²

1. Department of General Surgery, Xuanwu Hospital, Capital University of Medical Sciences;2. Department of Physiology, Capital University of Medical Sciences

Received:1999-02-01 Revised:1900-01-01 Online:2000-01-15 Published:2000-01-15

摘要/Abstract

摘要： 为探讨梗阻性黄疸大鼠及其合并应激时胃电波和胃运动的变化,用SD大鼠建立梗阻性黄疸和约束水浸应激模型。实验动物共分4组：假手术对照组、梗阻性黄疸组、假手术应激组和梗阻性黄疸应激组,同步记录4组大鼠的胃电波和胃运动波。结果发现：梗阻性黄疸大鼠胃电慢波频率加快、胃运动频率显着加快,并伴有高频率的簇状收缩;受到应激刺激的黄疸大鼠运动振幅升高,频率下降,但同时仍有高频率的簇状收缩。提示：梗阻性黄疸及其合并应激时胃电慢波节律紊乱,并出现高频率的簇状收缩可能是导致胃蠕动功能障碍的生理基础。

关键词: 梗阻性黄疸, 胃电, 胃运动

Abstract: The purpose of this study was to determine the gastric electrical activity and motility in obstructive jaundice and stress rat. 41 adult SD rats were used and divided into 4 groups, i.e. sham operation , obstructive jaundice, sham operation stress and obstructive jaundice with stress group. The gastric electrical activity and motility were recorded at same time. Gastric electrical slow wave frequence and motive frequence were increased significantly in obstructive jaundice rat. After cold restrain stress, the amplitute of motility was increased and frequency was decreased obviously. The clustered contractions could be observed in the obstructive jaundice rat. The result suggested that gastric dysrythmias and high frequent clustered contraction may be physical basis of gastric motor dysfunction in obstructive jaundice and stress.

Key words: gastric electricity, motility, obstructive jaundice

中图分类号:

李非;孙家邦;刘爽;蔡伟;刘素梅;曲瑞瑶;曾文红;曲柏林. 梗阻性黄疸大鼠胃电及胃运动的实验研究[J]. 首都医科大学学报, 2000, 21(1): 46-48.

Li Fei;Sun Jiabang;Liu Shuang;Cai Wei;Liu Sumei;Qu Ruiyao;Zeng Wenhong;Qu Belin. Gastric Electric Activity and Motility in Obstructive Jaundice Rat[J]. Journal of Capital Medical University, 2000, 21(1): 46-48.

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[3]	李梦燕;刘学宗;孟晠;曲瑞瑶;金宗平;侯安存;张澍田;于中麟. 用计算机技术研究大鼠胃电和胃运动信号[J]. 首都医科大学学报, 1999, 20(3): 159-161.
[4]	曲瑞瑶;王荫槐;曲柏林;曾文红;赵铭. 无菌Wistar大鼠胃电与胃运动的观察[J]. 首都医科大学学报, 1996, 17(3): 177-182.
[5]	曲瑞瑶;曲柏林;曾文红. 家兔食欲中枢对胃电和胃肠运动的影响[J]. 首都医科大学学报, 1994, 15(1): 15-20.