首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (3): 212-213.

• 论著 • 上一篇    下一篇

尿毒症患者透析前后纤溶系统的变化及其临床意义

高国静1, 程翠玲2, 贾强1, 刘荣坤1   

  1. 1. 首都医科大学宣武医院肾脏内科;2. 宣武医院心血管内科
  • 收稿日期:2000-04-18 修回日期:1900-01-01 出版日期:2000-07-15 发布日期:2000-07-15

Clinical Significance and Variation of Fibrinolysis before and after Dialysis in Patients with Uremia

Gao Guojing1, Cheng Cuiling2, Jia Qiang1, Liu Rongkun1   

  1. 1. Renal Department, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Cardiology, Xuanwu Hospital
  • Received:2000-04-18 Revised:1900-01-01 Online:2000-07-15 Published:2000-07-15

摘要: 为探讨尿毒症患者纤溶系统的变化及透析对纤溶系统的影响,应用发色底物法和酶标法检测20例尿毒症患者透析前后及对照组的纤溶酶原(Plg)活性、组织性纤溶酶原激活剂(t-PA)活性、纤溶酶原激活剂抑制物(PAI)活性及D-二聚体(D-D)定量。发现尿毒症患者较对照组t-PA明显降低(P<0.01),D-D有所降低,PAI及Plg有所升高,而尿毒症患者透析前后纤溶系统各项指标均无明显变化。提示尿毒症患者纤溶系统活性下降,此作用不受透析的影响。

关键词: 尿毒症, 纤溶系统, 透析

Abstract: For investigating the variation of fibrinolysis in patients with uremia and the influence of dialysis on fibrnolysis, Plg, t-PA, PAI and D-D were examined in 20 patients with uremia and 13 healthy controls. It was found that t-PA was sousiderably higher in patients with uremia than in controls (P<0.01), D-D decreased and PAI and Plg increased, and there were no any differences before and after dialysis in patients with uremia. It was suggested that variation of fibrinolysis in patients with uremia is not influenced by dialysis.

Key words: uremia, fibrinolysis, dialysis

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