生长抑素八肽治疗急性重型颅脑损伤后应激性溃疡的疗效分析

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (3): 221-223.

生长抑素八肽治疗急性重型颅脑损伤后应激性溃疡的疗效分析

王嵘, 王德江, 赵元立, 富壮

首都医科大学附属北京天坛医院神经外科

收稿日期:1999-08-27 修回日期:1900-01-01 出版日期:2000-07-15 发布日期:2000-07-15

Evaluating the Effect of Sandostatin for Prevention and Treatment of Stress Ulceration in Acute Severe Brain Injury Patients

Wang Rong, Wang Dejiang, Zhao Yuanli, Fu Zhuang

Department of Neurosurgery, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences

Received:1999-08-27 Revised:1900-01-01 Online:2000-07-15 Published:2000-07-15

摘要/Abstract

摘要： 为评价生长抑素八肽对急性重型颅脑损伤后应激性溃疡的预防和治疗作用,对30例急性重型颅脑损伤患者(观察组),除常规的神经外科治疗外,同时给予生长抑素八肽制剂0.1mg快速静脉滴注,每8h1次,连续治疗1周,观察3周。对照组为86例同期急性重型颅脑损伤患者,给予常规抑酸治疗。结果：观察组仅4例(13.3%)出现上消化道出血,均在24h内停止出血;对照组16例出现上消化道出血,占18.6%.结果提示：生长抑素八肽能有效地预防急性重型颅脑损伤后应激性溃疡的发生,而对于已经发生上消化道出血的患者有满意的止血效果.

关键词: 生长抑素八肽, 急性重型颅脑损伤, 应激性溃疡

Abstract: To evaluate effect of Sandostatin in prevention and treatment of stress ulceration for acute severe brain injury patients, 30 patients with acute severe brain injury (GCS 3～8) were admitted into this study. Besides neurosurgery routine treatments, they received sandostatin during the first 7 days (0.1 mg, per 8 h) and were observed in the next 3 weeks. The other 86 patients with acute severe brain injury, as the controls, just received histamine H 2 antagonist treatment. Only 4 (13.3%) of the 30 patients in sandostatin group suffered from upper gastrointestinal hemorrhage, and all happened in the first 24 h and were controlled within 1 d. In the control group, 16 patients (18.6%) suffered from upper gastrointestinal hemorrhage(P<0.05). Conclusion: sandostatin is effective for prevention and treatment of the stress ulceration in acute sever brain injury patients.

Key words: sandostatin, acute severe brain injury, stress ulceration

中图分类号:

R651.1⁺⁵

王嵘;王德江;赵元立;富壮. 生长抑素八肽治疗急性重型颅脑损伤后应激性溃疡的疗效分析[J]. 首都医科大学学报, 2000, 21(3): 221-223.

Wang Rong;Wang Dejiang;Zhao Yuanli;Fu Zhuang. Evaluating the Effect of Sandostatin for Prevention and Treatment of Stress Ulceration in Acute Severe Brain Injury Patients[J]. Journal of Capital Medical University, 2000, 21(3): 221-223.

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