巯基物质对大鼠急性颅脑损伤应激性胃黏膜损伤胃黏膜结构的影响

首都医科大学学报 ›› 2003, Vol. 24 ›› Issue (3): 301-304.

巯基物质对大鼠急性颅脑损伤应激性胃黏膜损伤胃黏膜结构的影响

周婷婷¹, 杨昭徐², 崔培林²

1. 首都医科大学附属北京红十字朝阳医院综合科;2. 首都医科大学附属北京天坛医院消化内科

收稿日期:2002-04-03 修回日期:1900-01-01 出版日期:2003-07-15 发布日期:2003-07-15

Effect of Sulfhydryl Compounds on the Structure of Gastric Mucosa after Brain Trauma in Rats

Zhou Tingting¹, Yang Zhaoxu², Cui Peilin²

1. Department of General, Beijing Chaoyang Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Gastroenterology,Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences

Received:2002-04-03 Revised:1900-01-01 Online:2003-07-15 Published:2003-07-15

摘要/Abstract

摘要： 为观察巯基物质对大鼠急性颅脑损伤应激性黏膜损害胃黏膜结构的影响,采用改良Allen法制造大鼠颅脑损伤模型,将Wistar大鼠分为正常组、对照组、治疗组3组。治疗组在损伤前15min腹腔注射硫普罗宁300mg/kg,分别观察各组胃黏膜大体、光镜及电镜下结构改变。结果:对照组损伤后24h出现应激性黏膜损伤,而治疗组胃黏膜损伤明显减轻。提示:巯基物质对大鼠颅脑损伤应激性黏膜损伤胃黏膜细胞具有保护作用。

关键词: 巯基物质, 应激性黏膜损伤, 胃黏膜, 颅脑损伤

Abstract: To observe the effect of sulfhydryl compounds on the structure of brain trauma in rats, the models of brain trauma in rats were built by Allen's method. The rats were divided randomly into three groups: normal, contrast and treated. The rats in the treated group were injected with Tiopronic-prophylaxis (300 mg·kg^-1). The histopathologic changes of the gastric mucosa were investigated with light and electronic microscopes. The results showed that the stress ulcer could be observed in the contrast group and the gastric mucosa injury in the treated group decreased significantly. The results indicate that sulfhydryl compounds have cytoprotective effect on gastric mucosa after brain trauma in rats.

Key words: sulfhydryl compouds, stress related mucosal damage, gastric mucosa, brain trauma

中图分类号:

R651.1⁺5

周婷婷;杨昭徐;崔培林. 巯基物质对大鼠急性颅脑损伤应激性胃黏膜损伤胃黏膜结构的影响[J]. 首都医科大学学报, 2003, 24(3): 301-304.

Zhou Tingting;Yang Zhaoxu;Cui Peilin. Effect of Sulfhydryl Compounds on the Structure of Gastric Mucosa after Brain Trauma in Rats[J]. Journal of Capital Medical University, 2003, 24(3): 301-304.

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