急性早幼粒细胞白血病中白血病细胞CD117的表达

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (2): 227-229.

急性早幼粒细胞白血病中白血病细胞CD₁₁₇的表达

万岁桂¹, 徐娟¹, 巩文玉², 孙雪静¹, 田丁¹

1. 首都医科大学宣武医院血液科;2. 北京儿童医院血液中心

收稿日期:2003-04-06 修回日期:1900-01-01 出版日期:2004-04-15 发布日期:2004-04-15

Expression of CD₁₁₇ in Acute Promyelocytic Leukemia

Wan Suigui¹, Xu Juan¹, Gong Wenyu², Su Xuejing¹, Tian Ding¹

1. Department of Hematology, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Hematology, Beijing Children Hospital

Received:2003-04-06 Revised:1900-01-01 Online:2004-04-15 Published:2004-04-15

摘要/Abstract

摘要： 为观察CD₁₁₇分子在急性早幼粒细胞白血病(APL)中的表达及探讨其意义,采用三色流式细胞术对22例APL骨髓白血病细胞表面CD₁₁₇的表达进行分析。结果:CD₁₁₇在APL中的表达率为19/22,在急性粒细胞白血病(AMLM₁)和AMLM₂中的表达率分别为2/2和18/21。19例CD₁₁₇⁺的APL患者中,18例CD₃₄^-、HLA-DR^-,1例部分细胞HLA-DR⁺。提示:APL患者有较高水平的CD₁₁₇表达,CD₁₁₇与CD₃₄、HLADR联合进行多色流式细胞术分析,可用于APL微小残留病灶的检测。

关键词: 急性早幼粒细胞白血病, CD₁₁₇, 免疫分型, 微小残留病灶

Abstract: The aim was to investigate the expression of CD₁₁₇ in acute promyelocytic leukemia and its significance. The expression of CD₁₁₇ was detected using three-color flow cytometry. CD₁₁₇ was positive in 19/22 of patients with acute promyelocytic leukemia(APL), in 2/2 and 18/21 of patients with AML-M₁ and AML-M₂ respectively. Among nineteen APL patients with CD₁₁₇, eighteen were CD₃₄^- and HLA-DR^-. Only one patient was partial HLA-DR⁺. There was high level expression of CD₁₁₇ in acute promyelocytic leukemia. Minimal residual disease of APL can be detected using multi-color flow cytometry to analyze the expression of CD₁₁₇, CD₃₄ and HLA-DR.

Key words: acute promyelocytic leukemia, CD₁₁₇, immunophenotype, minimal residual disease

中图分类号:

R733.71

万岁桂;徐娟;巩文玉;孙雪静;田丁. 急性早幼粒细胞白血病中白血病细胞CD₁₁₇的表达[J]. 首都医科大学学报, 2004, 25(2): 227-229.

Wan Suigui;Xu Juan;Gong Wenyu;Su Xuejing;Tian Ding. Expression of CD₁₁₇ in Acute Promyelocytic Leukemia[J]. Journal of Capital Medical University, 2004, 25(2): 227-229.

急性早幼粒细胞白血病中白血病细胞CD₁₁₇的表达

Expression of CD₁₁₇ in Acute Promyelocytic Leukemia

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