禽流感危机

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (6): 695-698.

禽流感危机

王凯¹, 彭晓霞², 于琦¹, 陈凯¹, 孔德军¹, 曾婉利¹, 张萍¹, 齐银¹, 迟宓宓², 郭爱民², 王嵬^1,2

1. 中国科学院研究生院;2. 首都医科大学公共卫生与家庭医学学院流行病学与卫生统计学系

收稿日期:2005-11-20 修回日期:1900-01-01 出版日期:2005-12-24 发布日期:2005-12-24

The Threat of Avian Influenza A Viruses

Wang Kai¹, Peng Xiaoxia², Yu Qi¹, Chen Kai¹, Kong Dejun¹, Zeng Wanli¹, Zhang Ping¹, Qi Yin¹, Chi Mimi², Guo Aiming², Wang Wei^1,2

1. Graduate University of Chinese Academy of Science;2. Department of Biostatistics and Epidemiology, School of Public Health and Family Medicine, Capital University of Medical Sciences

Received:2005-11-20 Revised:1900-01-01 Online:2005-12-24 Published:2005-12-24

摘要/Abstract

摘要：

禽流感病毒的血凝素(hemagglutinin,HA)和神经氨酸酶(neuraminidase,NA)均易发生抗原漂移和抗原转换,可突变出快速感染人类并致病的亚型,特别是H5N1型具有从感染其他动物种属的流感病毒中获得基因并迅速转变的能力,威胁人类健康。世界候鸟的迁徙更使全球面临禽流感危急,本文就禽流感的病毒特征、感染机制及其防治和鸟类迁徙对禽流感传播的影响进行综述。

Abstract:

Hemagglutinin(HA) and Neuraminidase(NA) of influenza viruses are easy to have antigenic drift and antigenic shift, and new pathogenic subtype which is able to infect humans can be formed by such viral mutations.Genetic reassembly which always happens in H5N1 subtype accelerates the threat of avian influenza Aviruses to human being.In addition, bird migration contributes to the global spread of emerging infectious disease.Therefore, we review current knowledge regarding the harm, pathological properties, pathogenicity of avian influenza viruses and discuss the influence of bird migration to the global spread of the viruses.

中图分类号:

R181.3⁺2

王凯;彭晓霞;于琦;陈凯;孔德军;曾婉利;张萍;齐银;迟宓宓;郭爱民;王嵬;. 禽流感危机[J]. 首都医科大学学报, 2005, 26(6): 695-698.

Wang Kai;Peng Xiaoxia;Yu Qi;Chen Kai;Kong Dejun;Zeng Wanli;Zhang Ping;Qi Yin;Chi Mimi;Guo Aiming;Wang Wei;. The Threat of Avian Influenza A Viruses[J]. Journal of Capital Medical University, 2005, 26(6): 695-698.