难治性癫痫的病理学与多药耐药基因表达的研究

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (6): 714-718.

难治性癫痫的病理学与多药耐药基因表达的研究

丁成云^1,2, 徐群渊¹, 栾国明²

1. 首都医科大学北京神经科学研究所;2. 首都医科大学附属北京天坛医院癫痫中心

收稿日期:2004-12-15 修回日期:1900-01-01 出版日期:2005-12-24 发布日期:2005-12-24
通讯作者: 丁成云

The Study on Pathology and Expression of MDR1 in Human Intractable Epilepsy

Ding Chengyun^1,2, Xu Qunyuan¹, Luan Guoming²

1. Beijing Neuroscience Institute, Capital University of Medical Sciences;2. Neurosurgical InstituteEpilepsy Center of Beijing Tiantan Hospital, Capital University of Medical Sciences

Received:2004-12-15 Revised:1900-01-01 Online:2005-12-24 Published:2005-12-24

摘要/Abstract

摘要： 目的观察难治性癫痫患者的临床表现、手术获取脑组织的病理变化和多药耐药基因的表达并分析其相互关系。方法分析26例不同病因难治性癫痫患者的临床特征、术前评估、术中切除的脑组织在光镜和电镜下的病理变化以及多药耐药基因蛋白(MDR1)和胶质纤维酸性蛋白(GFAP)的表达。结果不同病因的难治性癫痫患者在发病年龄、癫痫发作形式等临床表现中存在着共同特征,都有神经元退行性损伤、反应性胶质细胞增生和MDR1高表达等病理学改变。结论不同病因的难治性癫痫患者存在着某些类似的病理学表现。

关键词: 难治性癫痫, 临床特征, 病理改变, MDR1和GFAP表达

Abstract: Objective To study the clinical characteristics, the pathological features, and the expression patterns of MDR1 and GFAPin intractable epilepsy patients with varied etiologies and to analyze the relations between clinical and pathological performances among those cases.Methods The clinical characteristics of strictly selected 26 intractable epilepsy patients were conduded and the pathological changes including the expression of MDR1 and GFAPfrom surgically resected tissues were analyzed systematically observed under light and electron microscopy.The relations between the clinical and pathological manifestutions of each subject were studied.Results There were certain common clinical characteristics, such as the onset of age and main types of seizure, which could be concluded in all studied cases, although the etiology of each subject may vary.Meanwhile some pathological changes including neuronal degeneration, reactive proliferation of astrocyte with over expression of GFAPand MDR1 appeared as the common features among all cases.Conclusion There are common pathological characteristics in the patients with intractable epilepsy, although the etiologies of them may vary.It may be resulted from recurrent epileptic ictus.

Key words: human intractable epilepsy, clinical characteristics, pathological characteristics, expression of MDR1 and GFAP

中图分类号:

R742.1

丁成云;徐群渊;栾国明. 难治性癫痫的病理学与多药耐药基因表达的研究[J]. 首都医科大学学报, 2005, 26(6): 714-718.

Ding Chengyun;Xu Qunyuan;Luan Guoming. The Study on Pathology and Expression of MDR1 in Human Intractable Epilepsy[J]. Journal of Capital Medical University, 2005, 26(6): 714-718.

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