Abstract: Tanycytes(TAs) are the specialized ependymal glia in central nervous system which locate mostly in the ventral wall of the ventricle Ⅲ and median eminence(ME).They have close relations with local cerebrospinal fluid, blood and neurons.Tanycytes are the common component of the brain barrier system, brain-CSFneurohumoral circuit and immune-neuroendocrine network.They naturally conduct the axonal regeneration process in the adult hypothalamus of mammal animals.Aseries of studies have shown that tanycytes can support the regeneration of the lesion axons in CNSand indicated that tanycytes may be a proper substrate for transplanting into injured spinal cord like the olfactory bulb ensheathing cells(OECs).This review focuses on tanycytes'origin, properties, studies in neuroregeneration and the possible mechanisms.