Abstract: Parkinson disease is a kind of neurodegenerative disease.The classic pathological finding of Parkinson disease is Lewy body(LB).Certain genic mutation would induce Parkinson disease, such as α-synuclein, Parkin, UCHL1 which are ascertained to be associated to Parkinson disease.These gene mutants damage the ubiquitin-proteasomes system(UPS), the UPSdysfunction would lead to Parkinson disease.This review focuses the relationship between the three gene mutant action and the ubiquitin-proteasome system.