围术期应用恩丹西酮预防术后恶心和呕吐的临床研究

首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (4): 549-552.

围术期应用恩丹西酮预防术后恶心和呕吐的临床研究

郑增旺, 王克杰

首都医科大学宣武医院麻醉科

收稿日期:2006-03-23 修回日期:1900-01-01 出版日期:2006-08-24 发布日期:2006-08-24

Clinic Study on Preventing Postoperative Nausea and Vomiting with Ondansetron During the Peroperative Period

Zheng Zengwang Wang Kejie

Department of Anesthesiology, Xuanwu Hospital, Capital University of Medical Sciences

Received:2006-03-23 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24

摘要/Abstract

摘要： 目的观察比较围术期应用恩丹西酮减少患者术后恶心、呕吐的程度.方法随机选择腹部和胸部手术患者各90例.分为3组:1)恩丹西酮Ⅰ组,术中静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL);2)恩丹西酮Ⅱ组,术中静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL),8 h后重复静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL);3)对照组,术中静滴生理盐水20 mL.结果恩丹西酮Ⅰ组、Ⅱ组术后恶心、呕吐发生率及程度均较对照组明显降低(P＜0.05).结论恩丹西酮对预防全麻患者术后恶心、呕吐的发生有显著效果.

关键词: 恶心, 呕吐, 恩丹西酮

Abstract: Objective Application of ondansetron is aimed at reducing the postoperative nausea and vomiting.Methods 180 patients who underwent abdomen or chest operation(90-each) were randomly divided into 3 groups.Ondansetron group Ⅰ: The patients received a bolus of ondansetron 4 mg(in normal saline 20 mL) intravenously during operations.Ondansetron group Ⅱ: The patients received a bolus of ondansetron 4 mg(in normal saline 20 mL) intravenously during operations,and repeatedly received ondansetron 4 mg(in normal saline 20 mL) 8 h there after.Control group: The patients received a bolus of normal saline 20 mL during operations.Results Observing the postoperative nausea and vomiting,it showed that the incidence and intensity of nausea for both group Ⅰ and Ⅱ after abdomen and chest operations were much lower than the control group(P<0.05).Conclusion Ondansetron has a significant effect on preventing the occurrence of postoperative nausea and vomiting.

Key words: nausea, vomiting, ondansetron

中图分类号:

R614.2

郑增旺;王克杰. 围术期应用恩丹西酮预防术后恶心和呕吐的临床研究[J]. 首都医科大学学报, 2006, 27(4): 549-552.

Zheng Zengwang Wang Kejie. Clinic Study on Preventing Postoperative Nausea and Vomiting with Ondansetron During the Peroperative Period[J]. Journal of Capital Medical University, 2006, 27(4): 549-552.

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