关键词: 同仁安神丸, 镇静安神, 惊厥, 药效学

Abstract: Objective To investigate the main pharmacological effects of Tongren'anshen Pill in vivo.Methods The mixture of the powdered ingredients(without honey) was administered peros to mice and the effects on independent activity,memory,sleeping and the prevention of nikethamide-induced convulsion and hemorrhagic anemia were observed.Results After administration of the mixture,the independent motion number of times was obviously reduced(P<0.05),but the memory was not influenced.For the nikethamide-induced convulsion,the incubation period was obviously prolonged(P<0.05).The survival time was prolonged,but not significant statistically.For the pentobarbital-induced sleeping,the sleeping-time was obviously prolonged(P<0.05).The incubation period was shortened significantly(P<0.05) and the number of mice falling a sleep under the threshold dose of pentobarbital was obviously increased(P<0.05).The Hb content in hemorrhagic mice was obviously increased(P<0.05).Conclusion Tongren'anshen Pill can tranquilize the mind and nourish the blood which are consistent with its clinical application.

Key words: Tongren'anshen pill, calm, convulsion, pharmacodynamics