首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (2): 142-145.

• 肾病学专题 • 上一篇    下一篇

非糖尿病血液透析患者颈总动脉僵硬度及相关因素

周亦伦1, 于泽兴2, 郭瑞君2, 孙芳1, 马丽洁1, 彭立人1, 贾慧敏3, 王清涛3, 崔太根1   

  1. 1. 首都医科大学附属北京朝阳医院肾内科;2. 首都医科大学附属北京朝阳医院超声诊断科;3. 首都医科大学附属北京朝阳医院检验科
  • 收稿日期:2009-01-18 修回日期:1900-01-01 出版日期:2009-04-21 发布日期:2009-04-21
  • 通讯作者: 崔太根

Determinants of Arterial Distensibility in Non-diabetic Hemodialysis Patients

ZHOU Yi-lun1, YU Ze-xing2, GUO Rui-jun2, SUN Fang1, MA Li-jie1, PENG Li-ren1, JIA Hui-min3, WANG Qing-tao3, CUI Tai-gen1   

  1. 1. Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University;2. Department of Ultrasonic Medicine, Beijing ChaoYang Hospital, Capital Medical University;3. Department of Laboratory Medicine, Beijing ChaoYang Hospital, Capital Medical University
  • Received:2009-01-18 Revised:1900-01-01 Online:2009-04-21 Published:2009-04-21

摘要: 目的 评价非糖尿病血液透析患者颈总动脉僵硬度,探讨可能影响颈总动脉僵硬度的危险因素。方法 采用超声Echo-tracking技术测定80例非糖尿病血液透析患者的颈总动脉可扩张性系数(distensibility coefficient,DC),作为评价颈总动脉僵硬度的指标,常规检测白蛋白、总胆固醇、高密度脂蛋白、低密度脂蛋白、三酰甘油、血糖、肌酐、钙、磷、甲状旁腺素、超敏C反应蛋白。结果 颈总动脉DC为(14.47±5.19)(10-3/kPa),多元逐步回归分析显示收缩压(β=-0.340,P<0.01)、年龄(β=-0.248,P<0.05)、血钙(β=-0.199,P<0.05)与颈总动脉DC独立相关。结论 收缩压、年龄及血钙升高是非糖尿病血液透析患者颈总动脉僵硬度增加的独立危险因素。

关键词: 动脉僵硬度, 血液透析, 非糖尿病

Abstract: Objective To evaluate the arterial stiffness in non-diabetic hemodialysis patients and to investigate the risk factors for arterial stiffness. Methods A total of 80 non-diabetic hemodialysis patients were recruited. The distensibility coefficient(DC) of the common carotid artery was evaluated by an ultrasonic phase-locked echo-tracking system. Serum albumin, total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein(LDL), triglyceride(TG), glucose, creatinine, high sensitive C-reactive protein(hs-CRP), calcium, phosphorus, and intact parathyroid hormone(iPTH) were determined with standard methods. Results Carotid DC was(14.47±5.19)(10-3/kPa) in the non-diabetic hemodialysis patients studied. In stepwise multiple regression analysis, systolic blood pressure(β=-0.340, P<0.01), age(β=-0.248, P<0.05), and serum calcium(β=-0.199, P<0.05) were independently correlated with carotid DC. Conclusion Systolic blood pressure, age, and serum calcium were independent determinants for carotid arterial stiffness in non-diabetic hemodialysis patients.

Key words: arterial stiffness, hemodialysis, non-diabetic

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