虎眼万年青和其他3种抗癌中草药的微量元素含量及其溶出特性

首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (2): 208-211.

虎眼万年青和其他3种抗癌中草药的微量元素含量及其溶出特性

白进发¹, 刘志强², 张瑞萍¹, 宋凤瑞², 刘淑莹²

1. 中国医学科学院北京协和医学院药物研究所仪器分析中心;2. 中国科学院长春应用化学研究所长春质谱中心

收稿日期:2008-10-06 修回日期:1900-01-01 出版日期:2009-04-21 发布日期:2009-04-21
通讯作者: 白进发

Content and Dissolution Characteristics of Trace Elements in Ornithogalum Caudatum Ait and Three Anticancer Chinese Herbs

BAI Jin-fa¹, LIU Zhi-qiang², ZHANG Rui-ping¹, SONG Feng-rui², LIU Shu-ying²

1. Instrumental Analysis Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College;2. Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Received:2008-10-06 Revised:1900-01-01 Online:2009-04-21 Published:2009-04-21

摘要/Abstract

摘要： 目的对虎眼万年青和其他3种抗癌中草药(白花蛇舌草、半枝莲和山豆根)中16种常量和微量元素及溶出率进行比较,为阐明虎眼万年青抗癌作用提供依据。方法采用等离子体原子发射光谱法,辅以原子吸收光谱法和原子荧光光谱法进行有关检测。结果 1)虎眼万年青含有多种人体必需的常量和微量元素,特别是Ca、Mg、Fe、Zn含量较高;2)虎眼万年青和其他3种中草药水煎液中Cu/Zn比值比较低;3)4种中草药水煎液中Se含量较低,差异无统计学意义。Ge在4种中草药的原生药或水煎液中的含量均较低。结论虎眼万年青可能通过调节肿瘤患者体内Cu、Zn及Ca等元素的平衡发挥其抗癌、抗炎性反应作用。

关键词: 虎眼万年青, 微量元素, 溶出率, 电感耦合等离子体原子发射光谱法

Abstract: Objective To provide basis for the anticancer effect of Ornithogalum Caudatum Ait, the content and dissolution rates of 16 elements in Ornithogalum Caudatum Ait and three anticancer Chinese herbs(Herba Hedyotis Diffusa, Herba Scutellariae Barbatae and Radix Sophorae Tonkinensis) were investigated and compared. Methods Samples were analyzed by inductively coupled plasma atomic emission spectrometry(ICP-AES), atomic absorption spectrometry(AAS) and atomic fluorescence spectrometry(AFS). Results 1 There were many essential elements in Ornithogalum caudatum Ait and the content of Ca, Mg, Fe, and Zn were higher than those of others; 2 The ratios of Cu/Zn in water extract of Ornithogalum Caudatum Ait and the three anticancer Chinese herbs were much lowe than the normal value in human serum; 3 The differences in the contents of Se in water extracts of four Chinese herbs were very small and the contents were low. The contents of Ge in four crude herbs and their water extracts were very low. Conclusion The anticancer and anti-inflammatory effects of Ornithogalum Caudatum Ait is probably achieved by adjusting the balance among Cu, Zn, and Ca elements. The results provide basis for further analysis of the relevance between the elements in Ornithogalum Caudatum Ait and its therapeutic effect.

Key words: Ornithogalum Caudatum, trace element, dissolution rate, ICP-AES

中图分类号:

R 917

白进发;刘志强;张瑞萍;宋凤瑞;刘淑莹. 虎眼万年青和其他3种抗癌中草药的微量元素含量及其溶出特性[J]. 首都医科大学学报, 2009, 30(2): 208-211.

BAI Jin-fa;LIU Zhi-qiang;ZHANG Rui-ping;SONG Feng-rui;LIU Shu-ying. Content and Dissolution Characteristics of Trace Elements in Ornithogalum Caudatum Ait and Three Anticancer Chinese Herbs[J]. Journal of Capital Medical University, 2009, 30(2): 208-211.

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