非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究

doi:10.3969/j.issn.1006-7795.2015.05.022

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (5): 778-781.doi: 10.3969/j.issn.1006-7795.2015.05.022

非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究

张闻平¹, 吴静¹, 任美杰¹, 陈燕星², 李科纯², 杨佩仪², 杨坚伟², 王梦楠², 聂美玲²

1. 首都医科大学宣武医院超声诊断科, 北京 100053;
2. 首都医科大学第一临床学院, 北京 100053

收稿日期:2015-01-12 出版日期:2015-10-21 发布日期:2015-10-20
基金资助:
首都医科大学本科生科研创新课题资助(xsky2013072)。

Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin

Zhang Wenping¹, Wu Jing¹, Ren Meijie¹, Chen Yanxing², Li Kechun², Yang Peiyi², Yang Jiaxnwei², Wang Mengnan², Nie Meiling²

1. Department of Diagnostic Ultrasound, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
2. The First Clinic College, Capital Medical University, Beijing 100053, China

Received:2015-01-12 Online:2015-10-21 Published:2015-10-20
Contact: 吴静 E-mail:wj4628@163.com

摘要/Abstract

摘要： 目的探讨超声影像学诊断非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)与血清铁离子和血清铁蛋白浓度的相关性。方法应用经超声影像学方法诊断的40例非酒精性脂肪肝病者作为病例组及40例健康体检的非酒精性脂肪肝病者作为正常对照组,分别用原子吸收光谱法和放射免疫法检测血清铁和血清铁蛋白浓度。结果病例组的血清铁、铁蛋白测定值[(105.17±24.52)μg/dL,(146.57±68.28) ng/dL]与对照组[(85.45±26.84) μg/dL,(90.58±49.71) ng/dL]比较,差异有统计学意义(P<0.01)。应用血清铁诊断NAFLD的受试者工作特征(receiver operating characteristic, ROC)曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.69(P<0.01)、123.5 (μg/dL)、82.5%、60%、40 %、17.5%。应用铁蛋白诊断NAFLD的ROC曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.73(P<0.01)、134.9 (ng/dL)、75.0%、72.5%、27.5%、25.0%。结论 NAFLD患者血清铁和铁蛋白水平均出现升高,与超声诊断结果具有明显相关性。

关键词: 非酒精性脂肪性肝病, 血清铁, 铁蛋白, 超声诊断

Abstract: Objective To investigate the relationship between the nonalcoholic fatty liver disease (NAFLD) diagnosed by ultrasonography and serum iron and ferritin. Methods Forty patients with NAFLD (case group) and forty normal persons(control group) were examined by ultrasonic diagnosis, the levels of serum iron and serum ferritin were detected by atomic absorption spectrum method and radioimmunoassay respectively. Results The level of serum iron and serum ferritin in case group were (105.17±24.52)μg/dL,(146.57±68.28)ng/dL, the level of serum iron and serum ferritin in control group were (85.45±26.84)μg/dL,(90.58±49.71)ng/dL, respectively.The difference in serum iron and serum ferritin was significantly different between NFALD patients and normal control (P<0.01). The area under receiver operating characteristic (ROC) curve diagnosing NAFLD by serum iron and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.69(P<0.01),123.5 (μg/dL),82.5%,60%,40 %,17.5% respectively. The area under ROC curve diagnosing NAFLD by serum ferritin and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.73(P<0.01),134.9 (ng/dL),75.0%,72.5%,27.5%,25.0% respectively. Conclusion The levels of serum iron and serum ferritin were higher in NAFLD patients. The rise of serum iron and serum ferritin is coincide with NAFLD diagnosed by ultrasonography.

Key words: non-alcoholic fatty liver disease, serum iron, serum ferritin, ultrasonography

中图分类号:

Q575

张闻平, 吴静, 任美杰, 陈燕星, 李科纯, 杨佩仪, 杨坚伟, 王梦楠, 聂美玲. 非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究[J]. 首都医科大学学报, 2015, 36(5): 778-781.

Zhang Wenping, Wu Jing, Ren Meijie, Chen Yanxing, Li Kechun, Yang Peiyi, Yang Jiaxnwei, Wang Mengnan, Nie Meiling. Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin[J]. Journal of Capital Medical University, 2015, 36(5): 778-781.

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非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究

Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin

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