B细胞受体信号通路在B细胞淋巴瘤中的作用及靶向治疗策略

doi:10.3969/j.issn.1006-7795.2025.03.006

摘要/Abstract

摘要： B细胞淋巴瘤占非霍奇金淋巴瘤（non-Hodgkin lymphoma, NHL）的70%~80%，在发病机制、临床特征及预后方面等都展现出明显的异质性，为患者的临床治疗带来巨大挑战。B细胞受体（B cell receptor，BCR）是B细胞表面重要的跨膜受体，在B细胞存活、增殖、活化及免疫应答中发挥核心作用。BCR信号通路的功能异常促进了肿瘤B细胞的恶性增殖和抗凋亡能力，被认为是多种B细胞淋巴瘤发生发展的重要机制。因此，积极探索靶向BCR及其信号通路的治疗策略，已成为改善B细胞淋巴瘤临床治疗现状的重要任务。BCR及其相关信号通路在淋巴瘤的发病机制和临床治疗中占据核心位置，有望为未来开发治疗策略提供新方向和新希望。

关键词: B细胞淋巴瘤, B细胞受体, 信号通路, 小分子抑制剂, 免疫治疗

Abstract: B-cell lymphomas account for 70%－80% of non-Hodgkin lymphomas（NHL） and exhibit significant heterogeneity in genetic profiles, phenotypic characteristics, and clinical manifestations, posing substantial challenges for clinical management. The B-cell receptor (BCR) is a transmembrane receptor on the surface of B cells that plays a central regulatory role in B-cell development, activation, and adaptive immune responses. As a core mechanism driving malignant transformation in various B-cell malignancies, aberrant activation of the BCR signaling pathway, plays a pivotal role in B lymphoma pathogenesis. Dysregulated BCR signaling not only promotes tumor cell proliferation, survival, and anti-apoptotic capacity but also accelerates malignant progression. Consequently, researchers are vigorously exploring therapeutic strategies targeting BCR and its downstream pathways, including inhibitors of Bruton's tyrosine kinase (BTK) and PI3K, as well as direct BCR-targeted approaches. The central role of BCR signaling in lymphoma pathogenesis and treatment underscores its potential as a critical focus for future therapeutic development, offering new directions and hope for improved clinical outcomes.

Key words: B-cell lymphoma, B cell receptor, signal pathway, small molecule inhibitors, immunotherapy

中图分类号:

R733.1

汪婧雯, 李振军, 吕亮成, 姚晓雨, 丁宁. B细胞受体信号通路在B细胞淋巴瘤中的作用及靶向治疗策略[J]. 首都医科大学学报, 2025, 46(3): 436-441.

Wang Jingwen, Li Zhenjun, Lyu Liangcheng, Yao Xiaoyu, Ding Ning. B cell receptor signaling pathway and its therapeutic implications in B-cell lymphoma[J]. Journal of Capital Medical University, 2025, 46(3): 436-441.

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