胸腺瘤中生发中心的分布特征及其与重症肌无力的相关性研究

doi:10.3969/j.issn.1006-7795.2026.03.013

首都医科大学学报 ›› 2026, Vol. 47 ›› Issue (3): 514-519.doi: 10.3969/j.issn.1006-7795.2026.03.013

胸腺瘤中生发中心的分布特征及其与重症肌无力的相关性研究

李众¹,王聪慧²,王胜男³,付永娟³,赵莉红³,王亚叶⁴,滕梁红^3*

1. 雄安宣武医院病理科，河北雄安新区 070001；2. 河北医科大学第一医院病理科，石家庄 050000；3. 首都医科大学宣武医院病理科，北京 100053；4. 首都医科大学宣武医院神经内科，北京 100053

收稿日期:2026-01-20 修回日期:2026-03-25 出版日期:2026-06-21 发布日期:2026-06-26
通讯作者: 滕梁红 E-mail:tenglianghong@xwhosp.org
基金资助:
研究型病房卓越临床研究计划平行项目（BRWEP2024W022010112）。

Distribution characteristics of germinal centers in thymoma and their correlation with myasthenia gravis

Li Zhong¹, Wang Conghui², Wang Shengnan³, Fu Yongjuan³, Zhao Lihong³, Wang Yaye⁴, Teng Lianghong^3*

1.Department of Pathology, Xiongan Xuanwu Hospital, Xiongan New Area 070001, Hebei Province, China; 2.Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China; 3. Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 4. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2026-01-20 Revised:2026-03-25 Online:2026-06-21 Published:2026-06-26
Supported by:
This study was supported by the Outstanding Clinical Research Program of Research Ward ( BRWEP2024W022010112).

摘要/Abstract

摘要： 目的通过观测胸腺瘤中生发中心（germinal centers，GCs）数量与分布，分析其与胸腺瘤患者临床病理参数的相关性，为重症肌无力（myasthenia gravis，MG）患者的临床病程及预后评估提供新的参考指标。方法回顾性分析2019 年1月至 2025年6月期间首都医科大学宣武医院病理科诊断为胸腺瘤病例，将GCs与患者临床及病理资料结合进行分析。结果胸腺瘤合并MG病例中，GCs数量明显多于胸腺瘤不合并MG病例（P<0.001）。在胸腺瘤合并MG病例中，GCs数量梯度在Ⅰ型眼肌型和Ⅱ型全身型之间差异有统计学意义（P=0.039），且瘤周GCs数量明显多于瘤内（P=0.004）。结论 GCs与胸腺瘤患者临床病理参数存在一定相关性，并且与MG发生发展机制密切相关，GCs数量越多，则患者更易表现出MG症状，提示GCs可能是MG发生与进展的潜在监测指标。

关键词: 胸腺瘤, 重症肌无力, 生发中心, 自身免疫, 免疫微环境, 临床病理参数

Abstract: Objective To investigate the correlation between the number and distribution of germinal centers (GCs) in thymoma and clinicopathological parameters, and to explore its potential as a novel reference indicator for evaluating the clinical course and prognosis of patients with myasthenia gravis (MG). Methods A retrospective analysis was conducted on thymoma cases diagnosed in the Department of Pathology, Xuanwu Hospital, Capital Medical University, between January 2019 and June 2025. The GCs were analyzed in relation to patients' clinical and pathological characteristic. Results The number of GCs was significantly higher in thymoma cases complicated with MG compared to those without MG (P＜0.001). Among MG-complicated thymoma cases, a significant difference was observed in the gradient of GCs numbers between type Ⅰ (ocular) and type Ⅱ (generalized) MG (P=0.039). Additionally, the number of peritumoral GCs was significantly greater than that of intratumoral GCs (P=0.004). Conclusion GCs show certain correlations with clinicopathological parameters in thymoma patients and are closely related to the pathogenesis and progression of MG. A higher number of GCs is associated with a increased risk of MG symptoms, These findings suggest that GCs may serve as a potential monitoring indicator for the occurrence and progression of MG.

Key words: thymoma, myasthenia gravis, germinal centers, autoimmunity, immune microenvironment, , clinicopathological parameters

中图分类号:

李众, 王聪慧, 王胜男, 付永娟, 赵莉红, 王亚叶, 滕梁红. 胸腺瘤中生发中心的分布特征及其与重症肌无力的相关性研究[J]. 首都医科大学学报, 2026, 47(3): 514-519.

Li Zhong, Wang Conghui, Wang Shengnan, Fu Yongjuan, Zhao Lihong, Wang Yaye, Teng Lianghong. Distribution characteristics of germinal centers in thymoma and their correlation with myasthenia gravis[J]. Journal of Capital Medical University, 2026, 47(3): 514-519.

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胸腺瘤中生发中心的分布特征及其与重症肌无力的相关性研究

Distribution characteristics of germinal centers in thymoma and their correlation with myasthenia gravis

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