辛伐他汀对血脂、载脂蛋白A1、B100及hs-CRP的影响

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (4): 474-475.

辛伐他汀对血脂、载脂蛋白A₁、B₁₀₀及hs-CRP的影响

刘琦, 常志文

首都医科大学附属北京同仁医院干部医疗科

收稿日期:2004-11-30 修回日期:1900-01-01 出版日期:2005-08-24 发布日期:2005-08-24

Effects of Simvastatin on apoA₁, apoB₁₀₀ and High Sensitive CRP on Hypercholesterolernia

Liu Qi, Chang Zhiwen

Department of Geriatrics, Beijing Tongren Hospital, Capital University of Medical Sciences

Received:2004-11-30 Revised:1900-01-01 Online:2005-08-24 Published:2005-08-24

摘要/Abstract

摘要：

目的探讨辛伐他汀调脂治疗对高脂血症患者载脂蛋白A₁(apoA₁)、apoB₁₀₀及高敏C反应蛋白(hs-CRP)的影响。方法选择79例原发性高脂血症患者,辛伐他汀治疗前后检测血脂、apoA₁、apoB₁₀₀及hs-CRP的变化。结果治疗后血清胆固醇、低密度脂蛋白、apoB₁₀₀明显降低(P＜0.01),apoA₁/apoB₁₀₀比值明显增高(P＜0.05),hs-CRP水平明显降低(P＜0.01)。结论辛伐他汀除具有显著调脂作用外,还可减轻炎性反应,多途径抑制动脉粥样硬化的发生和发展.

关键词: 辛伐他汀, 载脂蛋白A₁, 载脂蛋白B₁₀₀, 高敏C反应蛋白

Abstract:

Objective To evaluate the effects of simvastatin on plasma apoprotein A₁（apoA₁）, apoB₁₀₀ and hs-CRP in hypercholesterolemia.Methods Serum cholesterol, apoA₁, apoB₁₀₀ and hs-CPR were determined before and after treatment with simvastatin 20 mg/d in 79 patients with hypercholesterolemia.Results After treatment with simvastatin, the serum cholesterol, apoB₁₀₀ as well as hs-CRP were significantly decreased（ P <0.01）. And the ratio apoA₁/apoB₁₀₀ was increased significantly（ P < 0.05 ）.Conclusion The lipid lowering treatment with simvastatin can not only decrease serum cholesterol, but also inhibit the inflammation. The results indicate that simvastatin can prevent the development of atherosclerosis by multiple ways.

Key words: simvastatin, apoA₁, apoB₁₀₀, hs-CRP

中图分类号:

R541.4

刘琦;常志文. 辛伐他汀对血脂、载脂蛋白A₁、B₁₀₀及hs-CRP的影响[J]. 首都医科大学学报, 2005, 26(4): 474-475.

Liu Qi;Chang Zhiwen. Effects of Simvastatin on apoA₁, apoB₁₀₀ and High Sensitive CRP on Hypercholesterolernia[J]. Journal of Capital Medical University, 2005, 26(4): 474-475.

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辛伐他汀对血脂、载脂蛋白A₁、B₁₀₀及hs-CRP的影响

Effects of Simvastatin on apoA₁, apoB₁₀₀ and High Sensitive CRP on Hypercholesterolernia

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