首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (4): 556-559.doi: 10.3785/j.issn.1006-7795.2009.04.032

• 临床研究 • 上一篇    下一篇

高敏C反应蛋白在急性冠脉综合征中的临床意义

杨敬, 华琦, 徐东, 谭静   

  1. 首都医科大学宣武医院心脏科
  • 收稿日期:2009-06-30 修回日期:1900-01-01 出版日期:2009-08-21 发布日期:2009-08-21

The Clinical Significance of High Sensitive C-reactive Protein in Patients with Acute Coronary Syndrome

YANG Jing, HUA Qi, XU Dong, TAN Jing   

  1. Department of Cardiology, Xuanwu Hospital, Capital Medical University
  • Received:2009-06-30 Revised:1900-01-01 Online:2009-08-21 Published:2009-08-21

摘要: 目的 探讨高敏C反应蛋白(high sensitive c-reactive protein,hs-CRP)在急性冠脉综合症患者中的改变以及在急性心肌梗死患者中随发病时间的变化趋势。方法 采用免疫比浊法对126例急性心肌梗死患者和135例不稳定型心绞痛患者进行hs-CRP检测, 并按照常规方法测定白细胞、中性粒细胞及血脂水平。同时对22例急性心肌梗死患者进行发病12 h之内、24 h、48 h、72 h时和7 d的hs-CRP检测,进行两两比较。结果 急性心肌梗死组hs-CRP水平(6.26±5.60 mg/L),明显高于不稳定型心绞痛对照组(3.52±4.34 mg/L),2组间差异有统计学意义(P=0.000)。2组间的白细胞和中性粒细胞差异有统计学意义,而总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和三酰甘油2组间差异无统计学意义(P>0.05)。22例急性心肌梗死患者发病48 h(13.05±3.89)mg/L或72 h(13.04±3.98)mg/L的hs-CRP水平较发病12 h内(5.34±5.45)mg/L明显增高。结论 hs-CRP在急性心肌梗死患者比不稳定型心绞痛患者明显增高。急性心肌梗死发病48 h或72 h的hs-CRP较发病12 h内更能反映急性冠脉事件的严重程度。

关键词: 高敏C反应蛋白, 急性冠脉综合症, 急性心肌梗死, 不稳定型心绞痛

Abstract: Objective To explore the changes of high sensitive c-reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS) and the variation tendency of hs-CRP in acute myocardial infraction(AMI) patients. Methods The single-centre study enrolled 126 acute myocardial infraction(AMI) patients and 135 unstable angina(UA) patients. The serum hs-CRP were measured by immune nephelometry. Leucocyte neutrophilic granulocyte and serum lipids(TC, LDL-C, HDL-C and TG) were also be measured. In 22 AMI patients, hs-CRP was measured at within 12 h, 24 h, 48 h, 72 h and 7 d. Results The levels of hs-CRP in patients with AMI(6.26±5.60 mg/ L ) were significantly higher than those in UA patients(3.52±4.34 mg/L)(P=0.000). The levels of leucocyte and neutrophilic granulocyte in AMI group were significantly higher than those in UA patients. There was no significant difference of the serum lipids(TC, LDL-C, HDL-C and TG) between the two groups(P>0.05). The levels of hs-CRP at 48 h or 72 h in AMI patients were significantly higher than those within 12 h. Conclusion The levels of hs-CRP in AMI patients are higher than those in UA patients. The levels of hs-CRP at 48 h or 72 h in AMI patients are superior to those within 12 h in reflecting the severity of AMI.

Key words: high sensitive c-reactive protein, acute coronary syndrome, acute myocardial infarction, unstable angina

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