益气养阴活血法对103例患者急性心肌梗死再灌注后心肌微循环的影响

doi:10.3785/j.issn.1006-7795.2009.04.005

首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (4): 426-429.doi: 10.3785/j.issn.1006-7795.2009.04.005

益气养阴活血法对103例患者急性心肌梗死再灌注后心肌微循环的影响

仇盛蕾¹, 金玫¹, 朱天刚², 权欣², 梁燕¹, 史大卓³, 李永强³, 易京红¹, 刘红旭¹

1. 首都医科大学附属北京中医医院心内科;2. 北京大学人民医院心内科;3. 中国中医科学院西苑医院心内科

收稿日期:2009-05-18 修回日期:1900-01-01 出版日期:2009-08-21 发布日期:2009-08-21
通讯作者: 金玫

Effect of Replenishing Qi and Nourishing Yin to Promote the Blood Circulation on 103 Patients with Acute Myocardial Infarction after Reperfusion

QIU Sheng-lei¹, JIN Mei¹, ZHU Tian-gang², QUAN Xin², LIANG Yan¹, SHI Da-zhuo³, LI Yong-qiang³, YI Jing-hong¹, LIU Hong-xu¹

1. Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University;2. Department of Cardiology, People's Hospital, Peking University;3. Division of Cardiology, Department of Internal Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Received:2009-05-18 Revised:1900-01-01 Online:2009-08-21 Published:2009-08-21

摘要/Abstract

摘要： 目的观察益气养阴活血法对再灌注治疗后急性心肌梗死(acute myocardial infarction,AMI)患者进行干预的临床疗效,探讨其对梗死部位心肌组织微循环血流的作用。方法 103例接受急诊直接经皮冠状动脉介入术(percutaneous coronary intervention,PCI)治疗后的AMI患者(Killip Ⅰ-Ⅲ),按照随机、对照、双盲的原则分为2组,治疗组(51例)在西药常规治疗基础上加用益气养阴活血的丹参和西洋参制剂,对照组(52例)在西药常规治疗基础上加用安慰剂,观察2组在治疗3个月后心肌微循环血流灌注的变化。结果在治疗3个月后,多巴酚丁胺负荷状态下,治疗组左心室射血分数(LVEF)增至68.40%±10.01%,正常心肌百分比(NCMP)增至89.61%±12.00%,A值显著改善的室壁节段数(NA)增至11.53±3.16,组间比较,治疗组LVEF、NCMP、NA均较对照组显著增加(P<0.05);2组治疗前后自身比较,治疗组LVEF值较治疗前增加显著(P<0.05);治疗前后组间比较,治疗组LVEF值与NA值增加大于对照组,差异有统计学意义(P<0.05)。结论益气养阴活血法可以有效改善AMI患者直接PCI术后的心肌微循环血流灌注,对心肌收缩储备改善有一定作用。

关键词: 益气养阴活血, 急性心肌梗死, 再灌注, 心肌声学造影

Abstract: Objective To evaluate the effect of replenishing Qi and nourishing Yin to promote the blood circulation on 103 patients with acute myocardial infarction(AMI) after reperfusion and observe the change of myocardial microcirculation. Methods A total of 103 patients with AMI who underwent successful immediate percutaneous coronary intervention(PCI) were randomized into two groups. Patients were treated with either Salvia and Ginseng of traditional Chinese medicine(TCM) group or fecula of corn in placebo group for three months. All patients were examined with myocardial contrast echocardiography(MCE) before and after 3-month treatment. Three indexes of myocardial microcirculation, i.e., left ventricular ejection fraction(LVEF), normal cardiac muscle percentage(NCMP), and the number of the segments where value A(contrast agent intensity) was improved significantly(NA) were assessed. Results Compared with the three indexes of the two groups at the 3rd month in the state of dobutamine stress(DS), all indexes were increased. After 3 months of treatment, LVEF, NCMP and NA of TCM group were higher than those of the placebo group(P<0.05 for all). LVEF of TCM group after 3-months treatment was higher than that of pre-treatment level(P<0.05). Compared with the three indexes between the two groups before and after treatment, LVEF and NA of TCM group increased significantly(P<0.05). Conclusion TCM with the effect of replenishing Qi and nourishing Yin to promote the blood circulation could be beneficial to myocardium microcirculation perfusion and improve the quality of life of the AMI patients who had successful reperfusion.

Key words: replenishing Qi and nourishing Yin to Promote the blood circulation, acute myocardial infarction, reperfusion, myocardial contrast echocardiography

中图分类号:

R 256.22

仇盛蕾;金玫;朱天刚;权欣;梁燕;史大卓;李永强;易京红;刘红旭. 益气养阴活血法对103例患者急性心肌梗死再灌注后心肌微循环的影响[J]. 首都医科大学学报, 2009, 30(4): 426-429.

QIU Sheng-lei;JIN Mei;ZHU Tian-gang;QUAN Xin;LIANG Yan;SHI Da-zhuo;LI Yong-qiang;YI Jing-hong;LIU Hong-xu. Effect of Replenishing Qi and Nourishing Yin to Promote the Blood Circulation on 103 Patients with Acute Myocardial Infarction after Reperfusion[J]. Journal of Capital Medical University, 2009, 30(4): 426-429.

[1]	苏文, 李虹伟, 陈晖, 李卫萍. 急性心肌梗死患者D二聚体质量浓度与远期预后的关系[J]. 首都医科大学学报, 2022, 43(2): 173-177.
[2]	鲍博艺, 李卫萍. 外泌体miRNA在急性心肌梗死中的研究进展[J]. 首都医科大学学报, 2022, 43(2): 199-204.
[3]	王向东, 姜敏, 王鑫, 巩永凤. 糖皮质激素受体在缺血再灌注肾损伤中的作用[J]. 首都医科大学学报, 2022, 43(2): 260-268.
[4]	房亚兰, 杨楠, 赵咏梅, 黄语悠, 李锦程, 段云霞, 高利, 罗玉敏. 大黄酚对局灶性脑缺血再灌注小鼠缺血半暗带区HIF-1α与VEGF表达的影响[J]. 首都医科大学学报, 2021, 42(2): 219-224.
[5]	杨楠, 丁锚, 闫峰, 师文娟, 黄语悠, 赵咏梅. 远隔缺血预适应对脑缺血再灌注损伤大鼠缺血半暗带区PERK/p-eIF2α通路及自噬的影响[J]. 首都医科大学学报, 2021, 42(2): 225-231.
[6]	丁锚, 杨楠, 黄语悠, 师文娟, 闫峰, 赵咏梅, 刘克建. 线粒体活性氧自由基抑制剂R(+)-普拉克索对脑缺血再灌注损伤大鼠JAK2-STAT3通路及炎性因子TNF-α的影响[J]. 首都医科大学学报, 2021, 42(2): 232-238.
[7]	杨楠, 丁锚, 黄语悠, 房亚兰, 师文娟, 赵咏梅. 一氧化氮在大鼠短暂性局灶性脑缺血损伤中对神经生长因子和脑源性神经营养因子表达的影响[J]. 首都医科大学学报, 2020, 41(6): 908-913.
[8]	王明洋, 孙争宇, 张丽, 李雅莉, 李林, 张兰. 山茱萸环烯醚萜苷对脑缺血再灌注大鼠线粒体损伤的影响[J]. 首都医科大学学报, 2020, 41(3): 385-390.
[9]	房亚兰, 黄语悠, 赵咏梅, 师文娟, 李锦程, 段云霞, 高利, 罗玉敏. 大黄酚对局灶性脑缺血再灌注小鼠Beclin1及Bax的作用[J]. 首都医科大学学报, 2019, 40(5): 703-708.
[10]	黄语悠, 房亚兰, 师文娟, 刘克建, 赵咏梅, 丁锚, 罗玉敏. 一氧化氮清除剂Carboxy-PTIO对短暂性局灶性脑缺血大鼠PERK/p-eIF2α通路的调节作用[J]. 首都医科大学学报, 2019, 40(5): 709-714.
[11]	师文娟, 赵咏梅, 戚智锋, 黄语悠, 房亚兰, 刘克建. 常压高浓度氧对脑缺血-再灌注大鼠缺血核心区核转录因子-κB的适度调节作用[J]. 首都医科大学学报, 2018, 39(3): 349-354.
[12]	房亚兰, 黄语悠, 赵咏梅, 李锦程, 段云霞, 高利, 罗玉敏. 大黄酚对局灶性脑缺血再灌注小鼠脑组织p-CREB、BDNF和p-STAT3的影响[J]. 首都医科大学学报, 2018, 39(3): 360-365.
[13]	崔旭, 纪方, 舒洛娃, 李俊发, 潘楚雄. cPKCγ膜转位在Herkinorin减轻MCAO小鼠脑缺血再灌注损伤中的作用[J]. 首都医科大学学报, 2017, 38(3): 336-341.
[14]	王潇, 苏跃, 李天佐, 赵斌江. 胆碱能抗炎通路对大鼠脑缺血再灌注损伤的影响[J]. 首都医科大学学报, 2017, 38(3): 342-347.
[15]	吴晴晴, 华琦, 薛淞, 张迎花, 司瑾, 李静. 白细胞计数与急性ST段抬高型心肌梗死病人直接经皮冠状动脉介入术中无复流的关系[J]. 首都医科大学学报, 2017, 38(3): 372-376.

益气养阴活血法对103例患者急性心肌梗死再灌注后心肌微循环的影响

Effect of Replenishing Qi and Nourishing Yin to Promote the Blood Circulation on 103 Patients with Acute Myocardial Infarction after Reperfusion

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价