安宫牛黄丸中汞、砷的存在形式及其吸收与排泄

首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (5): 647-651.

安宫牛黄丸中汞、砷的存在形式及其吸收与排泄

李珺¹, 袁倬斌², 韩树波², 朱敏²

1. 首都医科大学化学生物学与药学院;2. 中国科学院研究生院应用化学研究所

收稿日期:2005-10-17 修回日期:1900-01-01 出版日期:2006-10-24 发布日期:2006-10-24

The Existent Form of Mercury and Arsenium in Angong Niuhuang Wan and the Absorption and Excreting in Rats

Li Jun¹, Yuan Zhuobin², Han Shubo², Zhu Min²

1. School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences;2. Institute of Applied Chemistry, Graduate School, Chinese Academy of Sciences

Received:2005-10-17 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24

摘要/Abstract

摘要： 目的检测汞和砷在安宫牛黄丸中的存在形式及其在大鼠体内的吸收与排泄方式.方法用高效毛细管电泳检测安宫牛黄丸中汞络合物的存在形式,用冷原子吸收分光光度法和砷化氢发生法检测水飞朱砂和酸洗雄黄在人工胃液和肠液中溶出的汞、砷,以及大鼠口服硫化汞、硫化亚砷和安宫牛黄丸后排出的汞和砷.结果水飞朱砂从人工胃液和肠液中溶出的汞分别为0.003 05%和 0.000 04%,酸洗雄黄从人工胃液和肠液溶出的砷分别为0.033 75%和0.000 61%.大鼠服用硫化汞后24 h粪便检测结果显示超过90.195 0%汞被排出,服用硫化亚砷24 h后大鼠粪便中检测出26.437 9%的砷被排出,服用安宫牛黄丸24 h后82.830 9%的汞和24.442 0%的砷被排出.服用安宫牛黄丸120 h后大鼠粪便排出的汞和砷与服用硫化汞和硫化亚砷后排出的汞和砷差异无统计学意义.结论安宫牛黄丸中的汞在大鼠体内以络合物形式存在,大鼠口服硫化汞、硫化亚砷和安宫牛黄丸后汞和砷的吸收和排泄方式类似.

关键词: 安宫牛黄丸, 汞, 砷, 吸收, 排泄

Abstract: Objective To detect the existent form of mercury and arsenium in Angong Niuhuang Wan(ANW) and the absorption and excreting in rats.Methods The existent form of mercury was detected with high performance capillary electrophoresis.Mercury and arsenium of vermilion and realgar in artificial gastric and intestinal juice,and mercury and arsenium excreted out of rats fed with mercuric sulfide,arsenic disulfide and ANW were respectively tested with cold vapour-atomic absorption spectrometry and hydrogen arsenide based method.Results Mercury scutellarin was detected.Mercury of vermilion in artificial gastric and intestinal juice respectively was 0.003 05% and 0.000 04%.Arsenium in those Mercury and arsenium of vermilion and realgar were respectively was 0.033 75% and(0.000 61%).24 h later,more than 90.195 0% mercury was excreted out of rats fed with mercuric sulfide;26.437 9% arsenium was excreted out of rats fed with arsenic disulfide;82.830 9% mercury and 24.442 0% arsenium were excreted out of rats fed with ANW.The difference of excreted mercury and arsenium is not significant between rats fed with ANW and rats fed with mercuric sulfide and arsenic disulfide.Conclusion The absorption and excretion of mercury and arsenium from ANW,mercuric sulfide and arsenic disulfide in rats are analogical.

Key words: Angong Niuhuang Wan, mercury, arsenium, absorption, excreting

中图分类号:

R284.1

李珺;袁倬斌;韩树波;朱敏. 安宫牛黄丸中汞、砷的存在形式及其吸收与排泄[J]. 首都医科大学学报, 2006, 27(5): 647-651.

Li Jun;Yuan Zhuobin;Han Shubo;Zhu Min. The Existent Form of Mercury and Arsenium in Angong Niuhuang Wan and the Absorption and Excreting in Rats[J]. Journal of Capital Medical University, 2006, 27(5): 647-651.

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