首都医科大学学报 ›› 1989, Vol. 10 ›› Issue (4): 260-263.

• 论著 • 上一篇    下一篇

人乳头瘤病毒形态发生学的初步探讨

张利宁1, 高天祥2, 孙晔萍3   

  1. 1. 山东医科大学电镜室;2. 首都医学院电镜室;3. 山东医科大学附属医院中心实验室
  • 收稿日期:1989-03-02 修回日期:1900-01-01 出版日期:1989-10-15 发布日期:1989-10-15

A Early Study about Morphogenesis of Human Papillomavirus

Zhang Lining1, Gao Tianxiang2, Sun Yeping3   

  1. 1. Laboratory of Electron Microscopy, Shandong Medical University;2. Laboratory of Electron Microscopy, Capital Institute of Medicine;3. Centre Laboratory of Affiliated Hospiral, Shandong Medical University
  • Received:1989-03-02 Revised:1900-01-01 Online:1989-10-15 Published:1989-10-15

摘要: 利用透射电镜对11例寻常疣和2例蹠疣的超微病理进行了研究,并用免疫组织化学染色的方法对HPV抗原进行了定位,结果显示在表皮的基底细胞层和棘细胞中下层中,未发现病毒颗粒和病毒抗原,病毒颗粒和抗原主要存在于颗粒层的细胞核内及角化层,有时在棘细胞上层的细胞核内也可见到。此外,在棘细胞上层细胞核内可见到一些“前病毒颗粒”。

关键词: 人乳头瘤病毒, 免疫组织化学, 形态发生学

Abstract: Ultrastructure of eleven common warts and two plantar warts were studied by transmitional electron microscopy. HPV antigens were localizied by immunohistochemical staining. Results showed that there was no viral particals or antigen in the stratum basale and lower or middle stratum spinosum. The viruses and antigens were mainly found in stratum granulosum and corneum, sometimes in upper stratum spinusum. "Pre-virus particlesn" were seen in upper stratum spinusum. A morphogenetic course of HPV in squamous epithelial cells was discovered.

Key words: human papillomavirus, immunohistochemical staining, morphgenesis