关键词: 丙型肝炎, 糖尿病, 基因型, 肝硬化

Abstract: Objective To study the prevalence of abnormal glucose metabolism in patients with chronic hepatitis C and their clinical features and risk factors. Methods We retrospectively analyzed 152 patients with chronic hepatitis C(54 with liver cirrhosis) and 82 with chronic hepatitis B(30 with liver cirrhosis ). Results 1 The prevalence of impaired fasting glucose and diabetes mellitus in patients with chronic hepatitis C was 24.8% and 19.2%, respectively. The occurrence of diabetes mellitus in patients with liver cirrhosis was 25.9%, and in patients with child-pugh A, B and C the occurrence was 17.4%, 29.2%, 42.9%, respectively. 2 The prevalence of diabetes mellitus in patients with chronic hepatitis B was 9.7 %, and in liver cirrhosis(child-pugh C) was 6.7%. 3 The prevalence of type Ⅱ diabetes in patients with CHC was significantly higher than that in patients with CHB(P<0.01). 4 By Logistic regression analysis, risk factors associated with T2MD of CHC patients were genotype 1b, age, hypertensive, liver cirrohosis. Conclusion A considerable proportion of patients with CHC had abnormalities in glucose metabolism and type Ⅱ diabetes, and an increased prevalence of type Ⅱ diabetes was found associated with age, hypertension, genotype 1b and liver cirrhosis.

Key words: chronic hepatitis C, diabetes, genotype, liver cirrhosis