噻二嗪硫酮类化合物的合成与抑菌活性测定

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (3): 189-192.

噻二嗪硫酮类化合物的合成与抑菌活性测定

陈改清¹, 邹静恂¹, 朱莹¹, 李玉兰²

1. 首都医科大学化学教研室;2. 首都医科大学微生物学教研室

收稿日期:1900-01-01 修回日期:1995-05-11 出版日期:1996-07-15 发布日期:1996-07-15

Synthesis and Antimicrobial Activities of Some Novel 1, 3, 5-Thiadiazine-2-Thiones

Chen Gaiqing¹, Zou Jingxun¹, Zhu Ying¹, Li Yulan²

1. Department of Chemistry, Capital University of Medical Sciences;2. Department of Microbiology, Capital University of Medical Sciences

Received:1900-01-01 Revised:1995-05-11 Online:1996-07-15 Published:1996-07-15

摘要/Abstract

摘要： 合成了一系列新的噻二嗪硫酮衍生物,经元素分析、紫外光谱、红外光谱、核磁共振氢谱等证实了它们的结构,并试验了它们对6种细菌和2种霉菌的生物活性。结果显示此类化合物对革兰阴性菌的抑制作用强于对革兰阳性菌的抑制作用,对霉菌的活性较弱。

关键词: 抑菌活性, 噻二嗪硫酮类化合物, 抗菌药

Abstract: A number of novel 1, 3, 5-thiadiazine-2-thiones have been synthysized using benzylamine reacted with potassium hydroxide,carbon disulphide, formaldehyde and various amino acids.The structures of compounds have been elucidated by UV, IR, ¹H-NMR and elementary analysis.The activity of the compounds against 6 bacterias and 2 fungus was tested in vitro.All compounds were found to be potent against the gramnegative and less potent against the gram-positive and fungus.

Key words: antimicrobial activity, thiadiazinethiones, antimicrobial drug

中图分类号:

R914.5

陈改清;邹静恂;朱莹;李玉兰. 噻二嗪硫酮类化合物的合成与抑菌活性测定[J]. 首都医科大学学报, 1996, 17(3): 189-192.

Chen Gaiqing;Zou Jingxun;Zhu Ying;Li Yulan. Synthesis and Antimicrobial Activities of Some Novel 1, 3, 5-Thiadiazine-2-Thiones[J]. Journal of Capital Medical University, 1996, 17(3): 189-192.

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