首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (3): 193-196.

• 论著 • 上一篇    下一篇

癌患者的NK细胞和LAK细胞活性及MPS治疗对其的影响

陈海伦1, 王鸿2, 诸小侬2, 黄志刚2   

  1. 1. 首都医科大学微生物学教研室;2. 北京市耳鼻咽喉科研究所
  • 收稿日期:1900-01-01 修回日期:1995-12-11 出版日期:1996-07-15 发布日期:1996-07-15

NK and LAK Cell Activity of Cancer Patients and Effects of MPS on It

Chen Hailun1, Wang Hong2, Zhu Xiaonong2, Huang Zhigang2   

  1. 1. Department of Microbiology, Capital University of Medical Sciences;2. Beijing Institute of Otorhinolaryngology
  • Received:1900-01-01 Revised:1995-12-11 Online:1996-07-15 Published:1996-07-15

摘要: 观察了47例癌患者和13例健康人的NK细胞、内源性LAK细胞对靶细胞的杀伤活性及NK细胞计数。结果表明,癌患者该3项指标均显着低于对照组(P<0.001),尤以晚期癌症和发生远处转移患者的降低为着。不同种类的癌和有无淋巴结转移的患者之间该3项指标无显着性差异。使用MPS免疫治疗2周,可显着提高患者的上述3项指标(P<0.001、P<0.001、P<0.05).

关键词: 癌, NK细胞, LAK细胞, 分枝杆菌多糖

Abstract: The NK and endogenous LAK activity and the numbers of NK cell were observed in 47 cancer patients and in 13 healthy volunteers.The results revealed that the levels of the three indications were significantly lower in the patients than in the normal controled group(P<0.001) and the decline were conspicuous in the patients with late stage cancer and distant metastases.Treatment by mycobacterial polysaccharides (MPS) for two weeks has enhanced the levels of these indications in the patients after operation.

Key words: cancer, NK cell, LAK cell, mycobacterial polysaccharides

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