首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (1): 24-27.

• 论著 • 上一篇    下一篇

阿苯达唑与甲苯达唑对体外培养的猪囊虫作用的组织化学研究

陈佩惠1, 杨进2, 王秀琴2, 刘绍杰2, 王风芸2   

  1. 1. 首都医科大学寄生虫学教研室;2. 首都医科大学组织胚胎学教研室
  • 收稿日期:1995-04-14 修回日期:1900-01-01 出版日期:1996-01-15 发布日期:1996-01-15

Histochemical Observation on the Effects of Albendazole and Mebendazole on Cysticercus cellulosae in Vitro

Chen Peihui1, Yang Jin2, Wang Xiuqin2, Liu Shaojie2, Wang Fenyun2   

  1. 1. Department of Parasitology, Capital University of Medical Sciences;2. Department of Histology and Embryology, Capital University of Medical Sciences
  • Received:1995-04-14 Revised:1900-01-01 Online:1996-01-15 Published:1996-01-15

摘要:

比较了在含100mg/L浓度的阿苯达唑或甲苯达唑的培养液中培养72h后猪囊虫某些组织化学变化。研究结果表明,在2种药物分别作用于猪囊虫后,囊虫组织中的糖原、琥珀酸脱氢酶和三磷酸腺苷酶活性均明显下降;其中阿苯达唑组的糖原反应及2种酶活性均较甲苯达唑组弱。2个用药组酸性磷酸酶活性略减弱,而碱性磷酸酶活性均无明显变化。

关键词: 阿苯达唑, 甲苯达唑, 猪囊虫, 组织化学

Abstract:

By means of histochemical method, a comparative study on the effects of albendazole (Alb) and mebendazole(Meb)on histochemical changes of Cysticercus cellulosae in vitro after exposure to a dosage of 100 mg/L culture medium for 72 h was carried out.The experi ment enclosed three groups:Control group,Alb treated group and Meb treated group.The results showed that the contents of glycogen in tissues of the parasites in the groups treated with Alb or Meb were decreased obviously.The activities of succinate dehydrogenase and adenosine triphosphatase were declined apparently in two drug groups and more markedly in the Alb group than the Meb group.The activity of acid phosphatase was decreased slightly in the two drug treated groups, whereas the activity of alkaline phosphatase did not show apparently changes in the two drug treated groups.

Key words: albendazole, mebendazole, Cysticercus cellulosae, histochemistry

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