山蒟醇提取物的抗血小板聚集作用

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (1): 28-31.

山蒟醇提取物的抗血小板聚集作用

赵淑芬¹, 张建华¹, 韩桂秋²

1. 首都医科大学药理学教研室;2. 北京医科大学药学院

收稿日期:1995-01-06 修回日期:1900-01-01 出版日期:1996-01-15 发布日期:1996-01-15

The Inhibitory Effect of Alocoholic Extract of Piper hancei on Platelet Aggregation

Zhao Shufen¹, Zhang Jianhua¹, Han Guiqiu²

1. Department of Pharmacology, Capital University of Medical Sciences;2. Beijing Medical University

Received:1995-01-06 Revised:1900-01-01 Online:1996-01-15 Published:1996-01-15

摘要/Abstract

摘要： 以山蒟醇提取物在兔的体内和体外-体内进行抗血小板聚集实验。结果表明山蒟醇提取物可抑制由血小板活化因子和花生四烯酸所致的血小板聚集,对2者所致的血小板聚集(体外试验)的IC₅₀.分别为40. 34、345. 46 mg/L.静脉注射山蒟醇提取物30 mg/kg,15 min后产生的抗血小板聚集作用最明显,其对血小板活化因子和花生四烯酸所致的血小板聚集(体内-体外试验)的抑制率分别为82.75%和33.34%;血小板聚集的持续时间分别为60、30 min.这表明山蒟醇提取物对血小板活化因子作用有一定的选择性。

关键词: 山蒟, 血小板活化因子, 血小板聚集作用

Abstract: The antiplatelet effect of alcoholic extract of Piper hancei(PHE)was studied.It was shown that PHE inhibited rabbit platelet aggregation induced by platelet activating factor (PAF)and arachidonic acid(AA) either in vitro or ex vivo.The IC₅₀of PHE for PAF-induced platelet aggregation and for that of AA(in vitro)were 40.34 mg/L and 345.46 mg/L respectively.After iv of PHE (30 mg/kg),the maximum inhibitory rate for PAFinduced platelet aggregation and for that of AA(ex vivo)were 82.75% and 33.34% respectively;the duration of inhibitory effect for PAF-induced platelet aggregation and or that of AA were 60 min and 30 min respectively.PHE may exhibit certain selective anti-PAF activity.

Key words: Piper hancei Maxim, platelet activating factor, platelet aggregation

中图分类号:

R973.2

赵淑芬;张建华;韩桂秋. 山蒟醇提取物的抗血小板聚集作用[J]. 首都医科大学学报, 1996, 17(1): 28-31.

Zhao Shufen;Zhang Jianhua;Han Guiqiu. The Inhibitory Effect of Alocoholic Extract of Piper hancei on Platelet Aggregation[J]. Journal of Capital Medical University, 1996, 17(1): 28-31.

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