首都医科大学学报 ›› 1995, Vol. 16 ›› Issue (1): 48-51.

• 论著 • 上一篇    下一篇

精浆免疫抑制因子抗心脏移植后急性排异反应的大鼠实验研究

李温斌, 陈宝田, 石镜, 潘桂荣, 董冉, 赵莉敏   

  1. 北京市心肺血管医疗研究中心 首都医学院附属北京安贞医院
  • 收稿日期:1993-11-01 修回日期:1900-01-01 出版日期:1995-01-15 发布日期:1995-01-15

Immunosuppressive Factors of Human seminal Plasma Suppress Acute Ejection of Heart Transplatation in Rats

Li Wenbin, Chen Baotian, Shi Jing, Pan Guirong, Zhao Limin, Dong Ran   

  1. Beijing Heart-Lung-Blood Vessal Medical Center
  • Received:1993-11-01 Revised:1900-01-01 Online:1995-01-15 Published:1995-01-15

摘要: 选用Ono大鼠异位心脏移植模型和心脏移植后急性排异反应的体外模型,证实心脏移植后应用人精浆(human seminal plasma,HSP)免疫抑制因子具有明显的抗排异作用,能够抑制受体淋巴细胞对供体心肌细胞刺激的增殖反应,与环孢素A(CSA)相似。

关键词: 心脏移植排异反应, 人精浆, 免疫抑制因子, 大鼠

Abstract: Experiment has verified that HSP(human seminal plasma) can suppress acute rejection of heart transplantation in Ono rat in vivo model of heterotopic heart transplantation and transformation of the recipient's lymphocytes induced by donor's rat cardiomyoytes in vitro.The effect of immunosupression is similar to that of CSA (cyclosporine A).

Key words: heart transplantation, rejection, immunosuppressive factors of human seminal plasma, rat, CSA

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