家兔失血过程中的组织缺氧

首都医科大学学报 ›› 2008, Vol. 29 ›› Issue (4): 479-482.

家兔失血过程中的组织缺氧

张岩, 蒋鸿鑫, 陈玥

首都医科大学附属北京友谊医院实验中心

收稿日期:2006-03-20 修回日期:1900-01-01 出版日期:2008-08-24 发布日期:2008-08-24

Observation on the Changes of the Tissue Hypoxia in the Rabbits During Graded Progressive Hemorrhage

Zhang Yan, Jiang Hongxin, Chen Yue

Department of Central Laboratory, Beijing Friendship Hospital, Capital Medical University

Received:2006-03-20 Revised:1900-01-01 Online:2008-08-24 Published:2008-08-24

摘要/Abstract

摘要： 目的了解兔失血过程中血气变化和组织缺氧情况.方法用血气分析仪测量家兔(n=10)失血过程中动脉和混合静脉(右心室血)血气变化,比较血pH值、动脉血Hb与血乳酸浓度变化的关系.结果随心输出量(Q)降低,动-静脉pH差(AVpH)、动-静脉H+差(AVH⁺)、动-静脉二氧化碳分压差(AVPCO₂)进行性增大,血乳酸浓度逐渐升高.失血量和AVpH、AVH⁺、AVPCO₂以及血乳酸浓度呈相关关系,三者拐折点基本相同.此拐折点相当于临界供氧量(DO₂-crit).结论 AVpH和AVPCO₂突然增大提示组织缺氧的开始,可用于监测组织氧合情况.

关键词: 动-静脉血pH差, 动静脉二氧化碳分压差, 组织缺氧, 血流灌注不足

Abstract: Objective To understand the changes of the blood gas and the tissue hypoxia in rabbits during graded progressive hemorrhage.Methods The values of arteriovenous pH and PCO₂ gradients(AVpH and AVPCO₂) were compared with that of blood lactate in their relationship to changes in tissue oxygen delivery(DO₂) in 10 rabbits during graded progressive hemorrhage.Results AVpH,AVH⁺ and AVPCO₂ increased progressively as cardiac output(Qt) decreased,at the same time the blood lactate concentration increased.The relationship between cumulative blood loss,AVpH,AVH⁺,AVPCO₂ and blood lactate concentration was biphasic;In the early stage of hemorrhage,AVpH,AVH+,AVPCO₂ gradients and blood lactate concentration changed gradually and later these variables changed more rapidly.The inflection points in all cases were similar.The inflection point corresponds to the critical DO₂(DO₂-crit).Conclusion Rapidly expanding AVpH and AVPCO₂ indicates the onset of tissue hypoxia,which may serve as a repress reliable parameters of tissue hypoxia during hypoperfusion.

Key words: arteriovenous pH gradient, arteriovenous PCO₂ gradient, tissue hypoxia, hypoperfusion

中图分类号:

R594.3

张岩;蒋鸿鑫;陈玥. 家兔失血过程中的组织缺氧[J]. 首都医科大学学报, 2008, 29(4): 479-482.

Zhang Yan;Jiang Hongxin;Chen Yue. Observation on the Changes of the Tissue Hypoxia in the Rabbits During Graded Progressive Hemorrhage[J]. Journal of Capital Medical University, 2008, 29(4): 479-482.