新城鸡瘟病毒弱毒株对BT325细胞系多细胞球体的作用

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (3): 156-158.

新城鸡瘟病毒弱毒株对BT325细胞系多细胞球体的作用

李爱华¹, 潘李珍², 马鸿儒²

1. 首都医科大学生化教研室;2. 首都医科大学实验中心

收稿日期:1998-09-25 修回日期:1900-01-01 出版日期:1999-07-15 发布日期:1999-07-15

Effect of Newcastle Disease Virus Losota 4 on BT325 Multicellular Spheroids

Li Aihua¹, Pan Lizhen², Ma Hongru²

1. Department of Biochemistry, Capital University of Medical Sciences;2. Laboratory Center, Capital University of Medical Sciences

Received:1998-09-25 Revised:1900-01-01 Online:1999-07-15 Published:1999-07-15

摘要/Abstract

摘要： 为研究新城鸡瘟病毒(Newcastle diseasevirus,NDV)的抗肿瘤作用,观察了NDVLosota-4弱毒株对人脑多形胶质母细胞瘤细胞系BT325多细胞球体的杀伤效应。发现：随着培养时间延长,与对照组球体直径相比,各滴度试验组球体平均直径增长数明显减少(P<0.01);克隆率分析结果进一步证明,NDVLosota-4弱毒株能有效杀伤BT325肿瘤细胞(P<0.01).

关键词: 新城鸡瘟病毒, BT325多细胞球体, 抑制作用

Abstract: The cytotoxic effects of NDV vaccine Losota-4 on multicellular spheroids model of human glioblastoma multiform BT325 were investigated. The results indicated that the diameter of spheroid decreased in all NDV titer (P<0.01). Survival assay showed that NDV could effectively kill glioblastoma cell (P<0.01).

Key words: Newcastle disease virus, BT325 spheroid, inhibition action

中图分类号:

R329.28

李爱华;潘李珍;马鸿儒. 新城鸡瘟病毒弱毒株对BT325细胞系多细胞球体的作用[J]. 首都医科大学学报, 1999, 20(3): 156-158.

Li Aihua;Pan Lizhen;Ma Hongru. Effect of Newcastle Disease Virus Losota 4 on BT325 Multicellular Spheroids[J]. Journal of Capital Medical University, 1999, 20(3): 156-158.