药物流产后子宫刮出物的组织病理学和免疫细胞化学研究

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (2): 89-91.

药物流产后子宫刮出物的组织病理学和免疫细胞化学研究

房敬燕¹, 路欣², 许晴², 梁元晶², 诸定寿²

1. 首都医科大学宣武医院妇产科;2. 首都医科大学生殖医学研究中心

收稿日期:1998-09-16 修回日期:1900-01-01 出版日期:1999-04-15 发布日期:1999-04-15

Histopathological and Immunocytochemical Studies on Abstracted Tissue after Mifepristone Induced Abortion

Fang Jingyan¹, Lu Xin², Xu Qing², Liang Yuanjing², Zhu Dingshou²

1. Department of Gynecology and Obstetrics, Xuanwu Hospital,Capital University of Medical Sciences;2. Reproductive Medical Center, Capital University of Medical Sciences

Received:1998-09-16 Revised:1900-01-01 Online:1999-04-15 Published:1999-04-15

摘要/Abstract

摘要： 为探讨药物流产后阴道出血和子宫内膜中胎盘残留组织的关系,用组织病理学和免疫细胞化学方法,对药物流产后刮出组织(20例)和正常流出组织(10例)进行了研究。组织病理学显示:刮出内膜组织中都含有残留蜕膜组织,后者多数蜕膜细胞变性坏死,蜕膜和内膜都有大量炎性细胞浸润,并具有不同步发育的腺体和间质。免疫细胞化学方法显示:正常流出或刮出组织的毛细血管内皮因子Ⅷ相关抗原和胎盘碱性磷酸酶(PALP)呈阳性反应。残留的蜕膜组织中可见结构和功能正常的毛细血管。提示:子宫内膜中的炎细胞浸润,内膜不同步发育,残留蜕膜的某些部位因正常血液供应而继续生长,可能是药物流产后出血的原因。

关键词: 药物流产, 出血, 子宫内膜, 蜕膜, 免疫细胞化学

Abstract: To investigate the relation between bleeding after mifepristone induced abortion and placental remains in endometrium, histopathological and immunocytochemical methods were carried out to study the abstracted (20 patients) and aborted (10 patients) tissue. Histopathological study showed that there was decidua with necrotic cells in the abstracted tissue. A lot of white blood cells could be seen in decidua and endometrium. There were also glands and extracellular materials in different stages of development. Immunocytochemical study showed that factor Ⅷ antigen and PALP were positive in vascular endothelium. There were structurally and functionlly normal vassels in the remining decidua. This indicated that a lot of white blood cells in endometrium, the different development of endometrium, and the normal blood supply in the remining decidua which helps it to live could be the cause of bleeding after mifepristone induced abortion.

Key words: To investigate the relation between bleeding after mifepristone induced abortion and placental remains in endometrium, histopathological and immunocytochemical methods were carried out to study the abstracted (20 patients) and aborted (10 patients) tissue. Histopathological study showed that there was decidua with necrotic cells in the abstracted tissue. A lot of white bl, the different development of endometrium, and the normal blood supply in the remining decidua which helps it to live could be the cause of bleeding after mifepristone induced abortion.

中图分类号:

R714.21

房敬燕;路欣;许晴;梁元晶;诸定寿. 药物流产后子宫刮出物的组织病理学和免疫细胞化学研究[J]. 首都医科大学学报, 1999, 20(2): 89-91.

Fang Jingyan;Lu Xin;Xu Qing;Liang Yuanjing;Zhu Dingshou. Histopathological and Immunocytochemical Studies on Abstracted Tissue after Mifepristone Induced Abortion[J]. Journal of Capital Medical University, 1999, 20(2): 89-91.

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