垂体瘤手术对内分泌激素的影响

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (2): 99-102.

垂体瘤手术对内分泌激素的影响

张春芳, 范虹

首都医科大学附属北京天坛医院内分泌科

收稿日期:1998-09-11 修回日期:1900-01-01 出版日期:1999-04-15 发布日期:1999-04-15

The Effect of Adenomectomy on Endocrine Hormones

Zhang Chunfang, Fan Hong

Department of Endocrinology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences

Received:1998-09-11 Revised:1900-01-01 Online:1999-04-15 Published:1999-04-15

摘要/Abstract

摘要： 为了解垂体瘤手术对垂体激素分泌的影响,动态观察了150例垂体瘤患者在显微外科手术前后血清泌乳素(PRL)、生长激素(GH)、甲状腺功能〔T₃、T₄、促甲状腺素(TSH)〕、血皮质醇(F)和促肾上腺皮质激素(ACTH)的变化。结果:术后1周内PRL、GH水平明显下降且与以后的PRL、GH水平基本一致,故认为术后1周的PRL、GH水平可做为判断手术疗效的主要指标之一;所有垂体瘤患者T3术后较术前均显着降低,提示手术摘除垂体腺瘤可引起T₃水平的下降,而其他激素水平无明显变化。

关键词: 垂体肿瘤, 垂体激素, 显微外科手术

Abstract: 150 patients with pituitary adenoma (84 PRL secreting pituitary adenomas, 30 GH-secreting pituitary adenomas and 36 nonfunctioning pituitary adenomas) were treated by adnomectomy. The dynamic studies of serum PRL, GH, Cortisol, ACTH and thyroidal functions (T₃, T₄, TSH) were performed before and after microsurgery. PRL and GH levels decreased strikingly within one week after treatment and didnt change afterwards. It was concluded that PRLand GHlevels could be one of the major indicators to judge the effect of surgery. Serum T₃ also decreased significantly and the other pituitary hormones had no significant changes. It suggested that adenomectomy could cause the serum T₃ decreased.

Key words: pituitary adenoma, pituitary hormone, microsurgery

中图分类号:

R651.13

张春芳;范虹. 垂体瘤手术对内分泌激素的影响[J]. 首都医科大学学报, 1999, 20(2): 99-102.

Zhang Chunfang;Fan Hong. The Effect of Adenomectomy on Endocrine Hormones[J]. Journal of Capital Medical University, 1999, 20(2): 99-102.

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