首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (4): 269-271.

• 论著 • 上一篇    下一篇

慢性肝炎、肝硬化与消化性溃疡的研究

丁惠国1, 金瑞1, 胡中杰1, 于中麟2, 周亚华3   

  1. 1. 北京佑安医院消化内科;2. 首都医科大学附属北京友医院消化内科;3. 四平市肝病研究中心医院
  • 收稿日期:1998-06-15 修回日期:1900-01-01 出版日期:1999-10-15 发布日期:1999-10-15

Peptic Ulcerin Patients with of Gastroenterology,Chronic Liver Diseases

Ding Huiguo1, Jin Rui1, Hu Zhongjie1, Yu Zhonglin2, Zhou Yahua3   

  1. 1. Liver Unit of Beijing You'an Hospital;2. Department of Gastroenterology, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences;3. Liver Diseases Center Hospital of Siping
  • Received:1998-06-15 Revised:1900-01-01 Online:1999-10-15 Published:1999-10-15

摘要: 为研究肝源性溃疡(HPU)的临床特征及其可能的发病机制,分析了164例慢性肝病患者及36例急性肝炎患者的HPU发生情况,并观察了HPU患者血清微量元素变化。结果:①慢性肝病患者HPU发生率为40%,其中十二指肠球溃疡占88.8%;②平均发病年龄46.8岁;临床症状不典型;③HPU发生率与肝脏病变程度有关;④HPU患者血清Zn明显降低(P<0.05),Fe明显增加(P<0.05).结果提示,HPU不同于普通消化性溃疡;其病因和发病机制不完全清楚,可能是与肝病有关的胃粘膜攻击因子增强及防御因子减弱等多因素共同作用的结果。

关键词: 肝源性溃疡, 微量元素, 慢性肝炎, 肝硬化

Abstract: To study clinical and endoscopic feature and possible pathogenesis of hepatogenous peptic ulcer(HPU), The endoscopic and clinical materials were analysed and microelements of 164 patients with chronicliver diseases and 36 patients with acute hepatitis were detected by WFX 1Datomic absorption spectrophotometry.The incidence of HPU was 40 %.Of them, Duodenal ulcer accounted for 88.8 %.Average age was 46.8 year old.Atypicalsy mptomtic HPU was observed.Seru m Zn was decreased(P < 0.05) and Fe wasslightly increased(P < 0.05).The positive relationship between theincidence of HPU and the degree ofliver diseases was observed.The resultshowed that HPUdiffered from com mon peptic ulcer,and the pathogenesisis unclear.It was may be results from increased attactfactors and decreased protect factors in patients with chronicliver diseases.

Key words: hepatogenous peptic ulcer, microelement, chronic hepatitis, cirrhosis

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