关键词: 肝硬化, 估算肾小球滤过率, 传染病学调查

Abstract: Objective To analyze renal insufficiency and related factors in patients with liver cirrhosis and liver cancer, and to explain the importance of focusing on renal function in patients with cirrhosis, providing scientific basis for clinical medication. Methods The data of 4 040 patients with liver cirrhosis and liver cancer were analyzed statistically from November 2015 to November 2016 in Beijing Youan Hospital, Capital Medical University. Estimated glomerular filtration rate (eGFR) calculated by the formula recommended by The Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI) was used to assess the impaired renal function in the target population and the general factors affecting renal function was also analyzed. Results Patients with liver cancer accounted for 52% of 4 040 patients, and patients with liver cirrhosis accounted for 48%. Male patients were more than female patients, accounting for 79%, and the patients over the age of 50 were in majority, accounting for 79.6%. Of the 4 040 patients, 18.8% had varying degrees of renal insufficiency (eGFR<90 mL·min^-1·1.73 m^-2), approximately 68.6% of patients had mild renal insufficiency (60 mL·min^-1·1.73 m^-2-1·1.73 m^-2),23.5% had moderate renal insufficiency (30 mL·min^-1·1.73 m^-2-1·1.73 m^-2),7.9% of patients had severe renal insufficiency (eGFR<30 mL·min^-1·1.73 m^-2). 22.7% of patients over 50 years old showed renal insufficiency, the percentage was significantly higher than that under 40 years old (1.9%) and that between 40 years old and 50 years old (7.3%), the difference among the three groups was statistically significant (P<0.001). The proportion of renal insufficiency in male patients was lower than that in female patients (18.1% vs 21.1%, P=0.046). The proportion of renal insufficiency in out patients was lower than that in inpatients (10.7% vs 22.7%, P<0.001). The proportions of renal insufficiency in patients with alcoholic cirrhosis and liver cancer were significantly higher than those in patients with hepatitis B cirrhosis and hepatitis C cirrhosis(22.7%,18.1% vs 17.25, 16%, P=0.004). Conclusion The 4 040 cases of liver cirrhosis and liver cancer had milder renal insufficiency (60 < eGFR < 90 mL·min^-1·1.73 m^-2), and patients over the age of 50 years were in majority; inpatients may be more likely to develope kidney dysfunction than outpatients.

Key words: liver cirrhosis, estimated glomerular filtration rate, infectious diseases survey