不同年龄家兔单侧臂丛切断后后根神经节神经元数量的变化

首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (4): 288-291.

不同年龄家兔单侧臂丛切断后后根神经节神经元数量的变化

刘娜¹, 徐群渊², 景鹏¹, 蔡青², 杨连雪¹

1. 首都医科大学解剖学教研室;2. 首都医科大学神经科学研究所

收稿日期:2001-08-27 修回日期:1900-01-01 出版日期:2001-10-15 发布日期:2001-10-15

Changing of Neurons in the Dorsal Root Ganglion after an Injure of the Peripheral Nerve in Rabbits with Different Ages

Liu Na¹, Xu Qunyuan², Jing Peng¹, Cai Qing², Yang Lianxue¹

1. Department of Anatomy, Capital University of Medical Sciences;2. Beijing Institute for Neuroscience, Capital University of Medical Sciences

Received:2001-08-27 Revised:1900-01-01 Online:2001-10-15 Published:2001-10-15

摘要/Abstract

摘要： 为观察单侧臂丛切断术对不同年龄家兔脊髓颈膨大部C₄～T₂双侧后根神经节神经元数量变化的影响,对12例不同年龄的家兔行左侧臂丛切断术,3个月后对其脊髓颈膨大部C₄～T₂双侧后根神经节神经元进行观察计数,并对胞体及核仁的大小进行测量.细胞计数以核仁为指标,并根据Konigsmark法进行校正,对后根节的细胞及核仁的测量则借助图像分析仪进行,测量细胞共计1200个.结果显示臂丛切断侧脊髓颈膨大部后根节神经元缺失显着,后根节神经元缺失多发生在中、小型神经元,对年幼动物影响更为明显.

关键词: 后根神经元, 细胞数量, 臂丛切断

Abstract: To observe the changes of the cell body and nucleolus of neurons in the dorsal root ganglion of rabbits with different ages after an injure in the peripheral processes of those neurons, the brachial plexus were transected unilaterally in 12 rabbits in ages with 0, 1, 2, 3, 4 and 8 weeks, respectively. The cell numbers were counted and the sizes of cell bodies and nucleoli were measured bilaterally in the dorsal root ganglia from the segments of C₄～T₂ after 3 months of the operation. The nucleolus was selected as the counted unit and counted number was corrected according to K.. onigsmark's formula. The measurements of cell bodies and nucleoli were done with a device of image analyzer and 1 200 neurons were randomly selected to be measured. The results showed that the cell number of dorsal root ganglia from the lesion side of C₄～T₂ was markedly decreased compared with normal side after transecting of the plexus. The neurons with small or medium size were decreased even more distinctly among those decreased neurons. In addition, the cell loss was more seriously in younger animals than that in those older ones.

Key words: dorsal root ganglia, neuronal number, brachial plexus transaction

中图分类号:

R 338

刘娜;徐群渊;景鹏;蔡青;杨连雪. 不同年龄家兔单侧臂丛切断后后根神经节神经元数量的变化[J]. 首都医科大学学报, 2001, 22(4): 288-291.

Liu Na;Xu Qunyuan;Jing Peng;Cai Qing;Yang Lianxue. Changing of Neurons in the Dorsal Root Ganglion after an Injure of the Peripheral Nerve in Rabbits with Different Ages[J]. Journal of Capital Medical University, 2001, 22(4): 288-291.

[1]	张婷, 王晓民. 美国脑活动图谱计划解析[J]. 首都医科大学学报, 2013, 34(3): 472-474.
[2]	王会玲;周晓春;马春虎;王冰;王晓民. 雷公藤内酯醇对Aβ_1-42激活的小胶质细胞一氧化氮释放和诱导型一氧化氮合酶表达的影响[J]. 首都医科大学学报, 2012, 33(5): 643-646.
[3]	刘光伟;李瑛;李昕;李尧华;于顺. α-突触核蛋白促进MES23.5细胞突起生长[J]. 首都医科大学学报, 2011, 32(6): 759-763.
[4]	李瑛;刘光伟;李昕;李尧华;杨慧;于顺. α-突触核蛋白促进过氧化氢诱导的多巴胺能神经细胞凋亡[J]. 首都医科大学学报, 2011, 32(6): 771-776.
[5]	吴杨;苏玉金;李昕;刘光伟;李尧华;于顺. α-突触核蛋白在人脑膜瘤组织中的表达[J]. 首都医科大学学报, 2011, 32(6): 793-797.
[6]	丁月霞;;张丽;叶翠飞;王文;李林. 山茱萸环烯醚萜苷对穹隆海马伞切断大鼠海马区神经元存活和细胞凋亡调控因子的影响[J]. 首都医科大学学报, 2011, 32(1): 73-78.
[7]	张兰;刘芳;万岁桂;贾建平;李林. 阿尔茨海默病转线粒体DNA细胞模型胞质钙稳态的改变[J]. 首都医科大学学报, 2011, 32(1): 67-72.
[8]	冯波;胡鹏;王蓉. 突触后致密区与突触可塑性[J]. 首都医科大学学报, 2010, 31(1): 84-87.
[9]	王蓉;赵志炜;张丽;张兰;李林. 参乌胶囊及其有效成分二苯乙烯苷对老年大鼠海马神经元突触体素表达的影响[J]. 首都医科大学学报, 2010, 31(1): 60-64.
[10]	张景燕;王蓉;盛树力;姬志娟;孟祥宏;赵志炜. 胰岛素增敏剂罗格列酮对链脲佐菌素损伤SH-SY5Y细胞的保护作用[J]. 首都医科大学学报, 2010, 31(1): 69-71.
[11]	孟祥宏;赵志炜;姬志娟;张景燕;王蓉. APP5肽类似物P165及罗格列酮对Ⅲ型糖尿病大鼠学习记忆功能的影响[J]. 首都医科大学学报, 2010, 31(1): 65-68.
[12]	赵海燕;魏华;刘萍;刘廷会;王伟;黄海霞;钮伟真. 窦神经压力感受器聚类分析[J]. 首都医科大学学报, 2009, 30(5): 658-663.
[13]	高秀来;景鹏;郝彦利;马育平;陈亚亮;陆涛;韩凤岳;苏静;刘卫东;张平;常超英;刘恩. 中药对脊髓损伤大鼠背根神经节c-Jun表达的影响[J]. 首都医科大学学报, 2001, 22(4): 292-295.
[14]	谭宁;赵咏梅;赵志炜;姬志娟;盛树力. APP17肽对卵巢去势大鼠海马神经元凋亡相关因子表达的影响[J]. 首都医科大学学报, 2001, 22(4): 296-299.