尿毒症患者血清肌钙蛋白T测定的临床意义

首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (2): 141-143.

尿毒症患者血清肌钙蛋白T测定的临床意义

陈向东¹, 彭立人¹, 刘平²

1. 首都医科大学附属北京红十字朝阳医院肾内科;2. 北京医科大学第一医院肾内科

收稿日期:2000-05-29 修回日期:1900-01-01 出版日期:2001-04-15 发布日期:2001-04-15

Study of Cardiac Troponin T Assay in Asymptomatic Patients with Chronic Renal Failure

Chen Xiangdong¹, Peng Liren¹, Liu Ping²

1. Department of Nephrology, Beijing Red Cross Chaoyang Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Nephrology, the First Hospital of Beijing Medical University

Received:2000-05-29 Revised:1900-01-01 Online:2001-04-15 Published:2001-04-15

摘要/Abstract

摘要： 为探讨血清肌钙蛋白T(cTnT)在无症状尿毒症患者中的临床意义,分别抽取尿毒症非血液透析组、血液透析组透析前和透析后、骨骼肌损伤组、急性心肌梗死组和尿毒症合并心功能不全组病人的静脉血,以双抗体夹心法测定cTnT值,同时检测各组血肌酐(Cr)、肌酸磷酸激酶MB同工酶(CK-MB)、乳酸脱氢酶(LDH)及羟丁酸脱氢酶(HBD).结果显示:心肌梗死时,由于心肌大面积坏死致cTnT质量浓度明显升高;尿毒症合并心功能不全时cTnT质量浓度升高,但随心功能不全缓解,cTnT质量浓度恢复正常.而尿毒症非透析组、血透组透析前和透析后病人cTnT质量浓度与肾病对照组比较无显着性差异(P>0.01).提示:测定无症状尿毒症患者的cTnT对判断心肌受损无特殊临床意义.

关键词: 尿毒症, 血清肌钙蛋白T, 心肌损伤

Abstract: To identify the clinical significance of cardiac troponin T(cTnT)in asymptomatic patients with chronic renal failure(CRF), vein blood was drawn from patients with CRF of no hemodialysis(HD), maintenance HD, the skeletomuscular damage, the acute myocardial infarction and CRF with heart failure patients in proper order. Fullautomatic ELISA assay was used to determine cTnT serum levels, assay serum cretinine(Cr), creatine phosphate kinase-MB(CK-MB), lactic dehydrogenase(LDH)and hydroxybutyric acid dehydrogenase(HBD). The results is that during acute myocardial infarction, the mass density of cTnT increased significantly as a result of myocardial infarction. Blood cTnT was elevated in patients of CRF with heart failure. Blood cTnT fell to normal as soon as the heart failure was cured. But cTnT was not significantly elevated in asymptomatic patients with CRF. There was no clinical specificity for cTnT assay in asymptomatic patients with CRF.

Key words: chronic renal failure, cardiac troponin T, myocardial damage

中图分类号:

R692.5

陈向东;彭立人;刘平. 尿毒症患者血清肌钙蛋白T测定的临床意义[J]. 首都医科大学学报, 2001, 22(2): 141-143.

Chen Xiangdong;Peng Liren;Liu Ping. Study of Cardiac Troponin T Assay in Asymptomatic Patients with Chronic Renal Failure[J]. Journal of Capital Medical University, 2001, 22(2): 141-143.

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