SARS病人血清心肌同工酶水平分析

首都医科大学学报 ›› 2003, Vol. 24 ›› Issue (4): 444-446.

SARS病人血清心肌同工酶水平分析

田莉莉, 刘春玲, 张新卿, 左雅, 陈秀敏, 戚小红, 王小军, 朱秀云, 刘新

首都医科大学宣武医院

收稿日期:2003-07-23 修回日期:1900-01-01 出版日期:2003-10-15 发布日期:2003-10-15

Serum Myocardial Isoenzyme Level in SARS Patients

Tian Lili, Liu Chunling, Zhang Xinqing, Zuo Ya, Chen Xiumin, Qi Xiaohong, Wang Xiaojun, Zhu Xiuyun, Liu Xin

Xuanwu Hospital, Capital University of the Medical Sciences

Received:2003-07-23 Revised:1900-01-01 Online:2003-10-15 Published:2003-10-15

摘要/Abstract

摘要： 为分析严重急性呼吸综合征(SARS)病人血清肌酸激酶心肌型同工酶(CK-MB)的变化,用以发现早期急性心肌损伤,将204名SARS病人按年龄分为7组,选出每人住院期间测得的CKMB最高值,计算每组CK-MB异常患者的百分率及每组CKMB的平均值及标准差(x±s),并进行统计学分析。再将204名病人按CKMB是否正常分为2组,统计每组中多个肺叶病变患者的比例。结果CK-MB异常的百分率20岁以下组28%,21～30岁组12%,31～40岁组17%,41～50岁组22%,51～60岁组42%,61～70岁组33%,大于70岁组26%;CKMB值按上述顺序依次为(23±11)、(19±16)、(21±15)、(20±10)、(24±15)、(36±26)、(22±11)IU/L。CKMB异常组中多个肺叶病变患者占53%,CK-MB正常组为35%。提示部分SARS病人存在急性心肌损害,出现CKMB异常的百分比最高的年龄组为51～60岁组;CKMB平均值最高的年龄组为61～70岁组;CKMB异常组中多个肺叶病变患者明显高于CK-MB正常组。

关键词: 严重急性呼吸综合征, CK-MB, 心肌损害

Abstract: We analyzed the content of phospho creatine kinase myocardial isoenzyme(CK-MB)in the serum of SARS patients in order to find out acute myocardial damage in earlier SARS period.Methods:1)Altogether 204 patients were divided into7groups by age,and the highest CK-MB level was collected in every patient.The percentage of patients with abnormal CK-MB level were calculated and analyzed statistically.2)The patients then were divided into two groups,namely one group with normal CK-MB level and the other with abnormal level.The percentage of patients with multiple pathological changes in lung lobes was estimated for each group.Results:CK-MB abnormal percentages were:17%in the group aged below20;22%in the group aged between 41～50;26%in the group aged between 51～60.The average CK-MB levels in turn were(23±11),(19±16),(21±15),(20±10),(24±15),(36±26),and(22±11)IU/L.There were 53% patients with pathological changes in many lobes of lung in the abnormal group,and 35% in the normal group.Conclusions:Acute myocardial damage exists in part of SARS patients.The highest percentage of CK-MB abnormal level is in the group aged between 51～60years old.The highest average CK-MB level is in the group aged between 61～70years old.The percentage of patients with multiple pathological changes in lung lobes in the abnormal group is much higher than the normal group.

Key words: SARS, CK-MB, myocardial damage

中图分类号:

田莉莉;刘春玲;张新卿;左雅;陈秀敏;戚小红;王小军;朱秀云;刘新. SARS病人血清心肌同工酶水平分析[J]. 首都医科大学学报, 2003, 24(4): 444-446.

Tian Lili;Liu Chunling;Zhang Xinqing;Zuo Ya;Chen Xiumin;Qi Xiaohong;Wang Xiaojun;Zhu Xiuyun;Liu Xin. Serum Myocardial Isoenzyme Level in SARS Patients[J]. Journal of Capital Medical University, 2003, 24(4): 444-446.

[1]	郭彩霞, 曾翔俊, 杜凤和, 陈步星. 急性脑损伤致心肌损害中心肌G蛋白表达的改变[J]. 首都医科大学学报, 2015, 36(1): 111-115.
[2]	郭彩霞;张立克;芦玲巧;孙异临;杜凤和. 5-HT_2ARB对急性脑损伤致心肌损害及内源性去甲肾上腺素和5-羟色胺的影响[J]. 首都医科大学学报, 2010, 31(2): 222-227.
[3]	郭彩霞;杜凤和;张立克;芦玲巧;陈瑞芬;孙异临. 急性脑损伤致心肌损害及内源性5-羟色胺改变[J]. 首都医科大学学报, 2008, 29(3): 300-304.
[4]	彭堃;庞宝森;危天倪;是若春;王虹;庄蝶微;严梅. 严重急性呼吸综合征的临床特点及遗留肺纤维化相关因素分析[J]. 首都医科大学学报, 2006, 27(1): 43-47.
[5]	刘朝晖;华琦;张建. 轻症与重症SARS患者心理健康状况的队列研究[J]. 首都医科大学学报, 2006, 27(1): 74-77.
[6]	张霖;聂秀红;刘明芳. 严重急性呼吸综合征患者中性粒细胞CD11b的变化及意义[J]. 首都医科大学学报, 2006, 27(1): 87-89.
[7]	谢朝晖;刘改芬;单广良;潘利;乌正赉. 严重急性呼吸综合征家庭内传播特点及影响因素的研究[J]. 首都医科大学学报, 2005, 26(6): 655-661.
[8]	甄亚平;刘红;齐娜;单若明;王巧巧;吴晓东. SARS-CoV抗原化学发光免疫分析法的应用[J]. 首都医科大学学报, 2005, 26(3): 293-295.
[9]	郭彩霞;杜凤和;张立克;陈瑞芬;孙异临. 大鼠颅脑损伤后血管紧张素及其受体变化与B受体阻断剂对其的影响[J]. 首都医科大学学报, 2005, 26(3): 299-302.
[10]	张立洁;宋晨朝;郎振为;孟忻;张世杰;孙琳;李俊强. 3例SARS患者肺组织病理学观察及核转录因子-κB的表达[J]. 首都医科大学学报, 2004, 25(3): 332-334.
[11]	张天舸;张可;王曙照;郭新会. 95例SARS患者T细胞及其亚群动态变化的观察[J]. 首都医科大学学报, 2004, 25(3): 338-340.
[12]	孟艳英;王曙照;张可;黄春. 严重急性呼吸综合征死亡原因分析[J]. 首都医科大学学报, 2004, 25(3): 335-337.
[13]	周海. 3种成像技术在SARS检查中的价值[J]. 首都医科大学学报, 2004, 25(2): 262-263.
[14]	冯力民;王保国;李晶华;刘小春;焦强. 61例严重急性呼吸综合征临床分析[J]. 首都医科大学学报, 2004, 25(2): 212-214.
[15]	张连国;刘明芳;聂秀红;张霖;王烁;李小静;肖汉;杨强. 血小板数量对严重急性呼吸综合征患者预后的影响[J]. 首都医科大学学报, 2003, 24(4): 453-456.