首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (5): 656-660.doi: 10.3969/j.issn.1006-7795.2012.05.021

• 基础研究 • 上一篇    下一篇

经尿道电切术治疗的膀胱尿路上皮肿瘤病理特点及与预后相关性研究

罗静1, 张进生2, 王翠芝1, 刘宁2   

  1. 1. 首都医科大学附属复兴医院病理科, 北京 100038;2. 首都医科大学附属复兴医院泌尿外科, 北京 100038
  • 收稿日期:2012-06-14 修回日期:1900-01-01 出版日期:2012-10-21 发布日期:2012-10-21
  • 通讯作者: 张进生

Association of WHO2004 pathological classification of bladder urothelial tumors with the outcome

LUO Jing1, ZHANG Jin-sheng2, WANG Cui-zhi1, LIU Ning2   

  1. 1. Department of Pathology,Fuxing Hospital,Capital Medical University, Beijing 100038, China;2. Department of Urology,Fuxing Hospital,Capital Medical University, Beijing 100038,China
  • Received:2012-06-14 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

摘要: 目的 探讨世界卫生组织(World Health Organization,WTO)2004年采纳的尿路上皮肿瘤病理分类(WHO2004)对于肿瘤预后的价值。方法 采用WHO2004分类系统,回顾性总结384例经尿道电切术治疗的膀胱尿路上皮肿瘤的病理特点和随访结果。结果 单因素Kaplan-Meier 生存分析,Log-rank对数秩检验结果显示, 不同分类的肿瘤总体比较,肿瘤复发率、进展率、癌相关病死率差异有统计学意义(P<0.05),非浸润性乳头状癌(Ta)与癌细胞突破尿路上皮基底膜浸润至固有膜内的T1期肿瘤比较,肿瘤进展率和病死率差异有统计学意义(P<0.05)。结论 WHO2004尿路上皮肿瘤分类能够较好反映肿瘤的预后,高级别癌较低级别癌更具有侵袭性,肿瘤分级是肿瘤预后的重要指标。

关键词: 尿路上皮肿瘤, WHO病理分类, 预后, 复发

Abstract: Objective To evaluate efficacy of the 2004 World Health Organization (WHO)/International Society of Urological Pathology (ISUP) classification in prediction of recurrence, progression and cancer-specific mortality. Methods The dates of 384 patients who underwent transurethral resection of primary urothelial tumors were retrospectively studied. Results The difference of recurrence, progression and cancer-specific mortality rate among 6 groups was significant (P<0.05), and progression and cancer-specific mortality rate between Ta and T1 stage was significant (P<0.05). Conclusion WHO2004 pathological classification of urothelial tumors could well reflect the outcome of the patients with bladder urothelial tumors and it is useful to estimate the tumors progress.

Key words: urothelial tumors, WHO pathological classification, prognosis, recurrence

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