血清胎盘生长因子与冠状动脉侧支循环的关系

doi:10.3969/j.issn.1006-7795.2012.06.026

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (6): 833-836.doi: 10.3969/j.issn.1006-7795.2012.06.026

血清胎盘生长因子与冠状动脉侧支循环的关系

李晓涛¹, 魏立业², 任运军¹, 李强¹, 夏杨¹, 夏岳², 郭喜朝¹

1. 北京武警总队医院老年病科, 北京 100027;2. 河北医科大学附属第一医院心内科, 石家庄 050031

收稿日期:2012-08-24 修回日期:1900-01-01 出版日期:2012-12-21 发布日期:2012-12-21

Relationship between serum placental growth factor and coronary collateral circulation

LI Xiaotao¹, WEI Liye², Ren Yunjun¹, LI Qiang¹, XIA Yang¹, XIA Yue², GUO Xichao¹

1. Department of Geriatrics, Beijing Wujing Zongdui Hospital, Beijing 100027, China;2. Department of Cardiology, The First Affiliated Hospital, Hebei Medical University, Shijiazhuang 050031, China

Received:2012-08-24 Revised:1900-01-01 Online:2012-12-21 Published:2012-12-21

摘要/Abstract

摘要： 目的探讨冠状动脉粥样硬化性心脏病(以下简称冠心病,CHD)患者血清胎盘生长因子(placental growth factor,PlGF)浓度与冠状动脉侧支形成的关系。方法根据冠状动脉造影结果入选78例冠状动脉严重狭窄的CHD患者,按Rentrop方法进行冠状动脉侧支分级:0 级(23例),1级(23例),2级(18例),3级(14例),采用酶联免疫法检测患者血清PlGF浓度。结果冠状动脉侧支为0级、1级患者的PlGF血清水平均明显低于冠状动脉侧支为2、3级组患者(P<0.01);冠状动脉侧支分级与PlGF血清水平呈明显正相关(r=0.534,P<0.01)。结论在严重的CHD患者中,PlGF血清浓度与冠状动脉侧支分级呈明显正相关,提示PlGF可能有促进冠状动脉侧支循环形成的作用。

关键词: 侧支循环, 冠状动脉疾病, 胎盘生长因子

Abstract: Objective To investigate the relation between serum placental growth factor(PlGF) level and coronary collateral circulation(CCC) in patients with coronary artery disease. Methods A total of 78 patients with coronary artery disease(CAD) with severe coronary stenosis were included according to coronary angiography, CCC severities were divided into the following 4 degrees: degree 0(n=23), degree 1(n=23), degree 2(n=18), degree 3(n=14) by Rentrop method. Serum concentration of PlGF was measured by enzyme-linked immunosorbent assay(ELISA). Results Serum PlGF level in patients with CCC degree 0 and 1 was decreased as compared with that in CCC degree 2 and 3(P<0.01). The CCC degrees had a significant positive correlation with serum levels of PlGF(r=0.534, P<0.01). Conclusion In severe coronary artery disease, serum concentration of PlGF showed a significant positive correlation with coronary collateral circulation, suggesting that PlGF may be a factor that can enhance coronary collateral circulation.

Key words: collateral circulation, coronary artery disease, placental growth factor

中图分类号:

R541.4

李晓涛;魏立业;任运军;李强;夏杨;夏岳;郭喜朝. 血清胎盘生长因子与冠状动脉侧支循环的关系[J]. 首都医科大学学报, 2012, 33(6): 833-836.

LI Xiaotao;WEI Liye;Ren Yunjun;LI Qiang;XIA Yang;XIA Yue;GUO Xichao. Relationship between serum placental growth factor and coronary collateral circulation[J]. Journal of Capital Medical University, 2012, 33(6): 833-836.

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血清胎盘生长因子与冠状动脉侧支循环的关系

Relationship between serum placental growth factor and coronary collateral circulation

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