关键词: 冠状动脉疾病, 药物洗脱支架, 后扩张

Abstract:

Objective To assess the clinical effects of postdilatation with non-compliant balloons following implantation of drug-eluting stents(DES) in patients with coronary artery disease. Methods From January 2011 to July 2011, 356 consecutive patients underwent postdilatation with non-compliant balloons following implantation of DES at Beijing Anzhen Hospital, Capital Medical University. Via propensity score methodology, these patients were matched with 1 group of 356 patients who underwent DES without postdilatation during the same period. Results The two groups were similar for age, sex, clinical presentation, main risk factors and the features of coronary artery lesions. At 18-month follow-up incidence of major adverse cardiac events(MACE) was 10.1% in the postdilatation treatment group and 15.7% in routine un-postdilatation group(P=0.020), with a significant difference in target vessel revascularization and stent thrombosis(6.2% vs 10.7%, P=0.010; and 1.1% vs 3.7%, P=0.030, respectively).There were no statistical differences in myocardial infarction(AMI) and death rates in the two groups(3.9% vs 4.6%, P=0.700; 1.7% vs 1.3%, P=0.229; and 1.1% vs 1.7%, P=0.760, respectively). Conclusion Postdilatation after DES implantation in patients with coronary artery disease is safe and associated improved clinical outcomes.

Key words: coronary artery disease, drug-eluting stents, postdilatation