18F-FDG PET-CT在肺结核诊断中的研究进展

doi:10.3969/j.issn.1006-7795.2013.01.009

摘要/Abstract

摘要：

肺癌是最常见的恶性肿瘤之一,已成为恶性肿瘤最主要的死亡原因。目前中国每年大约有60万人死于肺癌,而且呈逐年上升的趋势。据预测,到2025年我国每年肺癌发病人数将会超过100万。肺癌的预后与临床分期密切相关,0期至Ⅳ期,5年生存率可由90%降到5%以下。因此, 早期发现、早期诊断肺癌对于延长肺癌患者的寿命、改善患者的生存质量具有十分重要的意义。在我国,¹⁸F-FDG PET-CT 的应用日趋广泛且日益增长,主要集中于肿瘤领域,特别是在肺癌、乳腺癌和结直肠癌等方面的应用。但¹⁸F-FDG不是肿瘤特异性的示踪剂,一些感染性或炎性反应相关的病变,特别是肺结核,对葡萄糖的摄取与代谢也增强。有效提高正电子发射计算机体层显像(positron emission tomography/computed tomography, PET-CT)检查中肺部病变的良恶性鉴别在临床实践中具有重要意义。

关键词: 肺结核, 脱氧葡萄糖, 正电子发射计算机体层显像

Abstract:

Lung cancer has been one of the most common malignant tumors, becoming the main cause of death among the malignant tumors in China. There are about 600,000 people dying of lung cancer each year in China now, showing an increasing trend year by year. It is predicted that China’s annual number of lung cancer will be over one million by 2025. The prognosis of lung cancer is closely related to the clinical stages, and the five-year survival rate is from 90% to below 5% from stage 0 to Ⅳ. Therefore, early detection and early diagnosis of lung cancer has a very important significance for prolonging the life of patients with lung cancer and improving the patient’s quality of life. In China, the application of ¹⁸F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) is increasingly widespread and growing, which is mainly used in tumor field, particularly including lung cancer, breast cancer and colorectal cancer, etc. However, the ¹⁸F-FDG is not a tumor-specific tracer and some lesions of infection or inflammation, especially tuberculosis, can also increase the glucose uptake and metabolism. The differentiation of benign and malignant lung disease is a major problem in the actual work of PET-CT examination. Solving this problem will be of a huge significance for clinical work.

Key words: tuberculosis, fluorodeoxyglucose, positron emission tomography/computed tomography(PET-CT)

中图分类号:

R817.4
R521

韩雪, 李亚明, 李雪娜. ¹⁸F-FDG PET-CT在肺结核诊断中的研究进展[J]. 首都医科大学学报, 2013, 34(1): 49-52.

HAN Xue, LI Yaming, LI Xuena. Research progress of ¹⁸F-fluorodeoxyglucose positron-emission tomography/computed tomography in the diagnosis of pulmonary tuberculosis[J]. Journal of Capital Medical University, 2013, 34(1): 49-52.

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¹⁸F-FDG PET-CT在肺结核诊断中的研究进展

Research progress of ¹⁸F-fluorodeoxyglucose positron-emission tomography/computed tomography in the diagnosis of pulmonary tuberculosis

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