卵巢早衰的颗粒细胞凋亡机制研究进展

doi:10.3969/j.issn.1006-7795.2014.03.023

首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (3): 379-383.doi: 10.3969/j.issn.1006-7795.2014.03.023

卵巢早衰的颗粒细胞凋亡机制研究进展

叶娜¹, 董晓英², 李冬华²

1. 首都医科大学基础医学院七年制临床医学专业, 北京 100069;
2. 首都医科大学中医药学院中医系中医基础教研室, 北京 100069

收稿日期:2013-12-17 发布日期:2014-06-14
通讯作者: 董晓英，E-mail：softsongs@126.com E-mail:softsongs@126.com
基金资助:
国家自然科学基金面上项目（81073096），首都医科大学学生科研创新项目（xsky2013048），首都医科大学基础临床合作课题（708016），北京中医药薪火传承"3+3"工程项目（2012-SZ-C-41）。

The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure

Ye Na¹, Dong Xiaoying², Li Donghua²

1. Clinical Medicine of a Seven-year Program, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;
2. Department of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China

Received:2013-12-17 Published:2014-06-14
Supported by:
This study was supported by National Natural Science Foundation of China(81073096), Student Research and Innovation Project of Capital Medical University(xsky2013048), the Basis and Clinical Cooperation Projects of Capital Medical University(708016), Eternal Flame Passing "3 +3" Project of Traditional Chinese Medicine in Beijing(2012-SZ-C-41).

摘要/Abstract

摘要：

卵巢早衰发病率日益增高，已经成为严重危害女性身心健康的疾病，近年来对其病因的研究很多，目前认为，造成这种疾病的原因是多方面的，主要有基因缺陷、激素及其受体缺陷、代谢紊乱以及自身免疫失常。此外，一些人为的机械性损伤，也可以诱发卵巢早衰，但其确切机制仍未可知。众多研究显示无论是何原因引起卵巢早衰，都伴有颗粒细胞的凋亡，这也说明了颗粒细胞的凋亡与卵巢早衰有着直接的关系。因此，本文就当前关于卵巢早衰中颗粒细胞凋亡的研究进展加以综述，提出卵巢早衰的细胞凋亡机制，旨在为后续研究提供参考。

关键词: 卵巢早衰, 细胞凋亡, 卵巢颗粒细胞, 颗粒细胞, 免疫调控

Abstract:

Premature ovarian failure(POF), with an increasingly higher and higher incidence, has become a serious disease which threatens female health in recent years. Many scholars have studied the etiology of it and found that the cause of this disease is multifaceted: genetic defects, hormone and its receptor defects, metabolic disorders and autoimmune disorders can all account for this disease. In addition, some artificial mechanical damage can also induce POF, but the exact mechanism is still unknown. No matter what cause above is the culprit, apoptosis of the granulosa cells concomitantly is widespread in the study, which shows it showed a direct relationship with POF. In this paper, current research progress of granulosa cells' apoptosis in POF will be reviewed and a mechanism of granulosa cells' apoptosis causing POF will be proposed, which aims to provide a reference for future research.

Key words: premature ovarian failure, apoptosis, ovarian granulosa cells, granulosa cells, immune regulation

中图分类号:

R271.11

叶娜, 董晓英, 李冬华. 卵巢早衰的颗粒细胞凋亡机制研究进展[J]. 首都医科大学学报, 2014, 35(3): 379-383.

Ye Na, Dong Xiaoying, Li Donghua. The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure[J]. Journal of Capital Medical University, 2014, 35(3): 379-383.

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卵巢早衰的颗粒细胞凋亡机制研究进展

The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure

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