亚肺叶切除治疗早期非小细胞肺癌

doi:10.3969/j.issn.1006-7795.2014.06.002

摘要/Abstract

摘要：

亚肺叶切除包括肺段切除和楔形切除,可用于部分高度选择的早期非小细胞肺癌。亚肺叶切除可以保存更多的肺功能,提高手术后生活质量。但存在肿瘤切除不彻底,增加手术后局部复发的风险。越来越多的证据显示,对于满足以下条件的非小细胞肺癌:IA期未发生淋巴结转移;肿瘤最大径≤2 cm;位于肺外周;尤其是没有实性成分的毛玻璃样结节,亚肺叶切除取得了和肺叶切除类似的治疗效果。目前的证据多来自回顾性临床研究,大规模的临床研究正在进行,已明确亚肺叶切除的确切疗效,在高等级的证据出现之前,肺叶切除术仍被认为是早期非小细胞肺癌的标准术式。

关键词: 非小细胞肺癌, 早期, 亚肺叶切除

Abstract:

Sublobectomy, include anatomic segmentectomy and non-anatomic wedge resection is an alternative to lobectomy for the surgical treatment of selected patients with early stage non-small cell lung cancer. Sublobar resection can reserve more pulmonary function in these patients. Emerging evidence suggests that sublobar resection may offer survival outcomes approaching that of lobectomy for lung cancer patients whose disease meets the following criteria: stage IA disease with no regional lymph node matastasis; tumor comes up to 2 cm in diameter; located in the periphery of lung; and predominantly ground-glass appearance on CT imaging. Compared with wedge resection, segmentectomy generated the best results. Nevertheless, the evidence is currently still limited, and the above criteria are met only in a minority of patients. Large randomized trials are underway to define the clinical role of sublobar resections, and results are eagerly anticipated. Until that time, lobectomy should still be regarded as the standard therapy for patients with early stage non-small cell lung cancer.

Key words: non-small cell lung cancer, early stage, sublobectomy

中图分类号:

R734.2

陈东红, 支修益. 亚肺叶切除治疗早期非小细胞肺癌[J]. 首都医科大学学报, 2014, 35(6): 689-693.

Chen Donghong, Zhi Xiuyi. Sublobectomy for early stage non-small cell lung cancer[J]. Journal of Capital Medical University, 2014, 35(6): 689-693.

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